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Psychopharmacology

, Volume 162, Issue 4, pp 415–418 | Cite as

High correlation between salivary MHPG and CSF MHPG

  • Thomas Reuster
  • Olaf Rilke
  • Jochen Oehler
Original Investigation

Abstract

Rationale. Determination of 3-methoxy-4-hydroxy-phenylglycol (MHPG) as a major metabolite of noradrenaline may reflect changes in noradrenergic activity dependent on psychiatric illness and drug therapy.

Objective. This study was designed to investigate the relationship between CSF and salivary MHPG, and thus the utility of saliva MHPG as a marker for CSF MHPG.

Method. Twenty-one paired samples of saliva and CSF were assayed for MHPG by solid-phase extraction and HPLC-ED.

Result. Salivary MHPG was highly positively correlated with CSF MHPG (P<0.001).

Conclusion. This finding supports the use of salivary MHPG as an index for CSF MHPG, and enhances the usefulness of salivary MHPG measurements as a non-invasive approach for clinical studies investigating noradrenergic systems.

CSF Metabolite 3-Methoxy-4-hydroxyphenylglycol Saliva 

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Copyright information

© Springer-Verlag 2002

Authors and Affiliations

  • Thomas Reuster
    • 1
  • Olaf Rilke
    • 1
  • Jochen Oehler
    • 1
  1. 1.Department of Psychiatry, Neurobiological Section, Carl Gustav Carus Hospital, Dresden University of Technology, Fetscherstrasse 74, 01307 DresdenGermany

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