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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 363, Issue 2, pp 241–244 | Cite as

Cannabinoid CB1-mediated inhibition of stress-induced gastric ulcers in rats

  • Maria Paola Germanò
  • Valeria D'Angelo
  • Maria Rita Mondello
  • Simona Pergolizzi
  • Francesco Capasso
  • Raffaele Capasso
  • Angelo A. Izzo
  • Nicola Mascolo
  • Rita De Pasquale
Short Communication

Abstract.

The effect of cannabinoid drugs (i.p.) on cold/restraint stress-induced gastric ulcers was studied in rats. The cannabinoid receptor agonist (WIN 55,212-2, 0.1–1 mg/kg), but not the less active isomer WIN 55,212-3 (1 mg/kg), reduced gastric ulceration. The protective effect of WIN 55,212-2 (1 mg/kg) was counteracted by the cannabinoid CB1 receptor antagonist SR141716A, but not by the cannabinoid CB2 receptor antagonist SR144528. These results indicate that the antiulcer effect of the cannabinoid receptor agonist WIN 55,212-2 is mediated by cannabinoid CB1 receptors.

Cannabinoid receptors Antiulcer activity Stomach Gastroprotection 

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Copyright information

© Springer-Verlag 2000

Authors and Affiliations

  • Maria Paola Germanò
    • 1
  • Valeria D'Angelo
    • 1
  • Maria Rita Mondello
    • 1
  • Simona Pergolizzi
    • 2
  • Francesco Capasso
    • 3
  • Raffaele Capasso
    • 4
  • Angelo A. Izzo
    • 3
  • Nicola Mascolo
    • 3
  • Rita De Pasquale
    • 1
  1. 1.Pharmaco-Biological Department, School of Pharmacy, University of Messina, Vill. Annunziata, 98168 Messina, Italy
  2. 2.Biomorphology Department, School of Medicine, University of Messina, Messina, Italy
  3. 3.Department of Experimental Pharmacology, University of Naples "Federico II", via D. Montesano 49, 80131 Naples, Italy
  4. 4.Department of Pharmaceutical Sciences, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy

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