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From diagnosis to resistance: a symphony of miRNAs in pheochromocytoma progression and treatment response

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Abstract

Pheochromocytoma (PCC) is a neuroendocrine tumor that produces and secretes catecholamine from either the adrenal medulla or extra-adrenal locations. MicroRNAs (miRNAs, miR) can be used as biomarkers to detect cancer or the return of a previously treated disease. Blood-borne miRNAs might be envisioned as noninvasive markers of malignancy or prognosis, and new studies demonstrate that microRNAs are released in body fluids as well as tissues. MiRNAs have the potential to be therapeutic targets, which would greatly increase the restricted therapy options for adrenal tumors. This article aims to consolidate and synthesize the most recent studies on miRNAs in PCC, discussing their potential clinical utility as diagnostic and prognostic biomarkers while also addressing their limitations.

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Acknowledgements

The authors are thankful to the Deanship of Scientific Research at University of Bisha for supporting this work through the Fast-Track Research Support Program. The authors would like to thank the Deanship of Scientific Research at Shaqra University for supporting this work.

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Authors and Affiliations

  1. Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231, Cairo, Egypt

    Elsayed G. E. Elsakka, Ahmed Elshafei, Mohamed A. Elkady, Amr Mohamed Yehia, Ahmed I. Abulsoud, Samy Y. Elkhawaga, Ahmed Ismail, Mahmoud Mohamed Mokhtar, Maghawry Hegazy & Hesham A. El-Mahdy

  2. Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, 11785, Egypt

    Ahmed I. Abulsoud & Nourhan M. Abdelmaksoud

  3. Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt

    Reem K. Shahin, Mahmoud A. Elrebehy, Mohammed S. Elballal & Ahmed S. Doghish

  4. Department of Clinical Pharmacology, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia

    Osama A. Mohammed

  5. Department of Pharmaceutical Sciences, College of Pharmacy, Shaqra University, 11961, Shaqra, Saudi Arabia

    Mustafa Ahmed Abdel-Reheim

  6. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Beni-Suef University, Beni Suef, 62521, Egypt

    Mustafa Ahmed Abdel-Reheim

  7. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt

    Walaa A. El-Dakroury

  8. Department of Pharmacology & Toxicology, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, 11829, Cairo, Egypt

    Sherif S. Abdel Mageed

  9. Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, 11231, Cairo, Egypt

    Ahmed S. Doghish

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  1. Elsayed G. E. Elsakka
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Contributions

HAE, O.A.M., A.I., M.A.A., A.I.A., Mo.A.E., N.M.A., S.Y.E., A.E., and A.S.D.: conceptualization, methodology, supervision, writing — original draft, review and editing. E.G.E.E., M.M.M., M.S.E., R.K.S., W.A.E, S.S.A., and M.H.: investigation, writing — original draft, data curation, methodology. Ma.A.E., A.I., A.M.Y., M.H., and H.A.E.: formal analysis, resources, visualization, writing — original draft, writing — review and editing.The authors confirm that no paper mill and artificial intelligence was used.

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Correspondence to Mustafa Ahmed Abdel-Reheim or Ahmed S. Doghish.

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Elsakka, E.G.E., Elshafei, A., Elkady, M.A. et al. From diagnosis to resistance: a symphony of miRNAs in pheochromocytoma progression and treatment response. Naunyn-Schmiedeberg's Arch Pharmacol 397, 1957–1969 (2024). https://doi.org/10.1007/s00210-023-02759-0

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