Abstract
Recently, various studies have been devoted to the study of transient receptor potential vanilloid member 1 (TRPV1)-related diseases, potential drugs, and related mechanisms. The objective of this investigation was to examine the significant areas and cutting-edge developments in TRPV1 study within recent decades. Articles or reviews were obtained from the Web of Science Core Collection. VOSviewer 1.6.18 and CiteSpace 6.1 R2 software were utilized to examine publication growth, distribution by country/region, institution, journal, authorship, references, and keywords. The software identified keywords with a high citation burstiness to determine emerging topics. From 1990 to 2023, the annual global publications increased by 62,000%, from 1 to 621. Journal of neuroscience published the most manuscripts and Nature produced the highest citations. The USA, Seoul National University and Di marzo V were the most productive and impactful institution, country, and author, respectively. “TRPV1,” “Capsaicin receptor,” “Activation,” and “Pain” are the most important keywords. The burst keywords “TRPV1 channel,” “Oxidative stress,” “TRPV1 structure,” and “Cancer” are supposed to be the research frontiers. The present study offers valuable insights into the understanding of TRPV1 and pain-related conditions. The research on TRPV1 has demonstrated a steady increase in studies related to pain-related diseases in the past few decades. The significance of TRPV1 in cancer pathogenesis and the resolution of its structure will emerge as a new academic trend in this field, providing direction for more widespread and comprehensive studies in the future.
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We gratefully acknowledge the Natural Science Foundation of China (82203845), the Natural Science Foundation of Liaoning Province (2022-MS-250), and the General project of Education Department of Liaoning Province (LJKZ0947, LJKZ0952).
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X.L, Y.J.X, and M.Y.Z conceived and designed the experiments. X.L drafted the paper. X.L, M.Y.Z, C.Y.H, S.B.J, and R.W.X analyzed the data. All authors revised the paper and approved the final manuscript. All authors agree to be accountable for all aspects of work ensuring integrity and accuracy. The authors confirm that no paper mill and artificial intelligence was used.
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Summary points
• It is first reported that the bibliometric study provided comprehensive overview on the publications of TRPV1 over the past two decades.
• The mechanism exploration of TRPV1 in the field of pain seemed to be the main research hotspot.
• Researchers have increasingly focused on the role of TRPV1 in cancer.
• TRPV1 structure solution might become the focus of future research, which might contribute to a deeper understanding of the mechanism of diseases and the development of drugs.
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Liu, X., Zhang, M., He, C. et al. Research focus and thematic trends of transient receptor potential vanilloid member 1 research: a bibliometric analysis of the global publications (1990–2023). Naunyn-Schmiedeberg's Arch Pharmacol 397, 1327–1346 (2024). https://doi.org/10.1007/s00210-023-02709-w
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DOI: https://doi.org/10.1007/s00210-023-02709-w