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Targeted cancer treatment using folate-conjugated sponge-like ZIF-8 nanoparticles: a review

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Abstract

ZIF-8 (zeolitic imidazolate framework-8) is a potential drug delivery system because of its unique properties, which include a large surface area, a large pore capacity, a large loading capacity, and outstanding stability under physiological conditions. ZIF-8 nanoparticles may be readily functionalized with targeting ligands for the identification and absorption of particular cancer cells, enhancing the efficacy of chemotherapeutic medicines and reducing adverse effects. ZIF-8 is also pH-responsive, allowing medication release in the acidic milieu of cancer cells. Because of its tunable structure, it can be easily functionalized to design cancer-specific targeted medicines. The delivery of ZIF-8 to cancer cells can be facilitated by folic acid-conjugation. Hence, it can bind to overexpressed folate receptors on the surface of cancer cells, which holds the promise of reducing unwanted deliveries. As a result of its importance in cancer treatment, the folate-conjugated ZIF-8 was the major focus of this review.

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Authors and Affiliations

  1. Department of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Mahsa Akbari Oryani & Mehdi Karimi-Shahri

  2. Department of Clinical Biochemistry, Faculty of Medicine, Azad Shahroud University, Shahroud, Iran

    Shamim Nosrati

  3. Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran

    Hossein Javid

  4. Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Hossein Javid & Alireza Hashemzadeh

  5. Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Hossein Javid

  6. Endoscopic and Minimally Invasive Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Ali Mehri

  7. Department of Pathology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran

    Mehdi Karimi-Shahri

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  1. Mahsa Akbari Oryani
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The first draft of the manuscript was written by Mahsa Akbari Oryani, Shamim Nosrati, Ali Mehri, and Alireza Hashemzadeh, and all authors commented on previous versions of the manuscript. The chemical analysis of this study was also conducted by Alireza Hashemadeh. Finally, all authors read and approved the final manuscript. Hossein Javid and Mehdi Karimi-Shahri were responsible for coordinating the authors and finalizing and submitting the paper. The authors confirm that no paper mill and artificial intelligence was used.

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Oryani, M.A., Nosrati, S., Javid, H. et al. Targeted cancer treatment using folate-conjugated sponge-like ZIF-8 nanoparticles: a review. Naunyn-Schmiedeberg's Arch Pharmacol 397, 1377–1404 (2024). https://doi.org/10.1007/s00210-023-02707-y

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