Abstract
Ovarian cancer cells usually spread in the peritoneal region, and if chemotherapeutic drugs can be given in these regions with proximity, then the anticancer property of the chemotherapeutic drugs can enhance. However, chemotherapeutic drug administrations are hindered by local toxicity. In the drug delivery system, microparticles or nanoparticles are administered in a controlled manner. Microparticles stay in a close vicinity while nanoparticles are smaller and can move evenly in the peritoneum. Intravenous administration of the drug evenly distributes the medicine in the target places and if the composition of the drug has nanoparticles it will have more specificity and will have easy access to the cancer cells and tumors. Among the different types of nanoparticles, polymeric nanoparticles were proven as most efficient in drug delivery. Polymeric nanoparticles are seen to be combined with many other molecules like metals, non-metals, lipids, and proteins, which helps in the increase of cellular uptake. The efficiency of different types of polymeric nanoparticles used in delivering the load for management of ovarian cancer will be discussed in this mini-review.
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Acknowledgements
D.B. and S.U. acknowledge Chettinad Academy of Research and Education for providing the PhD fellowship.
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We acknowledge Chettinad Academy of Research and Education for providing the CARE Seed Grant (No. Grant Number-Ref No. 004/Regr./AR-Research/2022–06).
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All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Sharon Sofini PS, Arina Guha, Balasubramanian Deepika, and Saranya Udayakumar. The concept of the manuscript was given by Koyeli Girigoswami, Agnishwar Girigoswami, Moupriya Nag, and Dibyajit Lahiri. The first draft of the manuscript was written by Sharon Sofini PS, Arina Guha, Balasubramanian Deepika, Saranya Udayakumar, and Koyeli Girigoswami, and all authors commented on previous versions of the manuscript. The final draft was written by Koyeli Girigoswami, Agnishwar Girigoswami, Moupriya Nag, and Dibyajit Lahiri. All authors read and approved the final manuscript. The authors confirm that no paper mill and artificial intelligence was used.
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PS, S.S., Guha, A., Deepika, B. et al. Nanocargos designed with synthetic and natural polymers for ovarian cancer management. Naunyn-Schmiedeberg's Arch Pharmacol 396, 3407–3415 (2023). https://doi.org/10.1007/s00210-023-02608-0
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DOI: https://doi.org/10.1007/s00210-023-02608-0