Abstract
Orientin is a flavone isolated from medicinal plants used in traditional Chinese medicine (TCM) that suppresses the growth of cancer cells in vitro. The effects of orientin in hepatoma carcinoma cells remain unknown. The aim of this paper is to investigate the effects of orientin on the viability, proliferation, and migration of hepatocellular carcinoma cells in vitro. In this study, we found that orientin could inhibit the proliferation, migration, and the activation of NF-κB signaling pathway in hepatocellular carcinoma cells. An activator of NF-κB signaling pathway, PMA, could abolish the inhibitory effect of orientin on NF-κB signaling pathway and proliferation and migration of Huh7 cells. These findings raise the possibility that orientin can be used in the treatment of hepatocellular carcinoma.
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Jia-Yi Tao, Jing Li, Mao-Lin Yi, and Li-Peng Wan participated in the research design, the analysis of the results, and the writing of the paper. Lu Wan, Bi-Zhen Dong, and Ye-Mao Liu performed the cell experiments in this investigation. Yong-Jie Yu was in charge of molecular biological associated detection. All authors reviewed the manuscript. The authors declare that all data were generated in-house and that no paper mill was used.
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Tao, JY., Li, J., Wan, L. et al. Orientin regulates the proliferation and migration of hepatocellular carcinoma cells. Naunyn-Schmiedeberg's Arch Pharmacol 396, 2519–2528 (2023). https://doi.org/10.1007/s00210-023-02472-y
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DOI: https://doi.org/10.1007/s00210-023-02472-y