Abstract
Comprehensive epidemiological analyses conducted in the last 30 years have revealed a link between radiation and DM. We aimed to determine the effects of dexmedetomidine pretreatment on radiation-induced pancreatic islet cell damage. Twenty-four rats were divided into three groups: group 1 (control group), group 2 (only X-ray irradiation group), and group 3 (X-ray irradiation + dexmedetomidine). We observed necrotic cells with vacuoles accompanying loss of cytoplasm in the islets of Langerhans, extensive edematous areas, and vascular congestions in group 2. In group 3, we observed a decrease in necrotic cells in the islets of Langerhans, and edematous areas and vascular congestion was also reduced. We determined a decrease in β-cells, α-cells, and D-cells in the islets of Langerhans in group 2 compared to the control group. In group 3, β-cells, α-cells, and D-cells were elevated compared to group 2. Ionizing radiation may induce DM. Dexmedetomidine appears to exert a radioprotective effect.
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Data Availability
The datasets used or analyzed during the current study are available from the corresponding author on reasonable request.
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F. M.: supervision, conceptualization, methodology, writing—original raft. L. T.: methodology, visualization, investigation. T. M.: software, data curation. S. Y. R.: methodology, data curation. S.C. and S.C.: writing—original raft.
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This experimental study was performed with approval from Recep Tayyip Erdogan University Animal Research Ethics Committee (Rize, Turkey; date: 30/06/2022; Approval Number: 2022/23).
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Mercantepe, F., Tumkaya, L., Mercantepe, T. et al. Radioprotective effects of α2-adrenergic receptor agonist dexmedetomidine on X-ray irradiation-induced pancreatic islet cell damage. Naunyn-Schmiedeberg's Arch Pharmacol 396, 1827–1836 (2023). https://doi.org/10.1007/s00210-023-02454-0
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DOI: https://doi.org/10.1007/s00210-023-02454-0