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Role of polyphenolic compounds and their nanoformulations: a comprehensive review on cross-talk between chronic kidney and cardiovascular diseases

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Abstract

Chronic kidney disease (CKD) affects a huge portion of the world’s population and frequently leads to cardiovascular diseases (CVDs). It might be because of common risk factors between chronic kidney disease and cardiovascular diseases. Renal dysfunction caused by chronic kidney disease creates oxidative stress which in turn leads to cardiovascular diseases. Oxidative stress causes endothelial dysfunction and inflammation in heart which results in atherosclerosis. It ends in clogging of veins and arteries that causes cardiac stroke and myocardial infarction. To develop an innovative therapeutic approach and new drugs to treat these diseases, it is important to understand the pathophysiological mechanism behind the CKD and CVDs and their interrelationship. Natural phytoconstituents of plants such as polyphenolic compounds are well known for their medicinal value. Polyphenols are plant secondary metabolites with immense antioxidant properties, which can protect from free radical damage. Nowadays, polyphenols are generating a lot of buzz in the scientific community because of their potential health benefits especially in the case of heart and kidney diseases. This review provides a detailed account of the pathophysiological link between CKD and CVDs and the pharmacological potential of polyphenols and their nanoformulations in promoting cardiovascular and renal health.

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Acknowledgements

The authors are highly grateful to Guru Nanak Dev University for their support.

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Authors and Affiliations

  1. Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, India

    Ankita Rajput, Palvi Sharma, Davinder Singh, Sharabjit Singh, Prabhjot Kaur, Shivani Attri, Pallvi Mohana, Harneetpal Kaur, Farhana Rashid, Astha Bhatia & Saroj Arora

  2. Institute for Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany

    Joachim Jankowski

  3. Sri Sukhmani Dental College & Hospital, Derabassi, Punjab, India

    Vanita Arora

  4. Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, 133207, India

    Hardeep Singh Tuli

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  1. Ankita Rajput
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Contributions

Ankita Rajput, Palvi Sharma, Davinder Singh, Sharabjit Singh, Prabhjot Kaur, Shivani Attri, Pallvi Mohana, Harneetpal Kaur, and Farhana Rashid contributed in writing manuscript; Astha Bhatia, Jaochim Jankowski, Hardeep Tuli, and Vanita Arora helped in editing the manuscript and gave suggestions and Saroj Arora conceived the idea.

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Correspondence to Saroj Arora.

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Key points

• CVD and CKD shares various common risk factors such as smoking, obesity, hypertension, diabetes mellitus, and dyslipidaemia.

• Polyphenolic compounds attenuate oxidative stress and ameliorates CVD and CKD.

• Nanoformulations of polyphenolic compounds improves their pharmacological potential achieving enhanced efficacy.

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Rajput, A., Sharma, P., Singh, D. et al. Role of polyphenolic compounds and their nanoformulations: a comprehensive review on cross-talk between chronic kidney and cardiovascular diseases. Naunyn-Schmiedeberg's Arch Pharmacol 396, 901–924 (2023). https://doi.org/10.1007/s00210-023-02410-y

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