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The modulation of sirtuins by natural compounds in the management of cisplatin-induced nephrotoxicity

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Abstract

Cisplatin is a highly effective antitumor agent. However, its use is limited due to severe adverse effects, particularly nephrotoxicity, which occurs in approximately 30% of patients. There is a need for novel renoprotective compounds. Sirtuins play a vital role in various physiological and pathological processes such as oxidative stress, apoptosis, inflammation, and mitochondrial bioenergetics. It has been shown that sirtuins can exert a protective effect on cisplatin-induced acute kidney injury by targeting multiple signaling pathways. Besides, sirtuins not only did not reduce the anticancer effect of cisplatin but also increased it. Several natural compounds have been reported to inhibit cisplatin-mediated nephrotoxicity through sirtuin stimulation. These compounds exert their therapeutic effects on cisplatin‐induced renal injury by targeting various signaling pathways including Sirt1/p53, Sirt1/NF-κb/p56, AMPK/Sirt1, Sirt1/PGC‐1α, and/or by enhancing mitochondrial function.

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Abbreviations

AKI:

Acute kidney injury

AMPK:

AMP-activated protein kinase

ATP:

Adenosine triphosphate

Bcl-2:

B cell lymphoma 2

BUN:

Blood urea nitrogen

COPD:

Chronic obstructive pulmonary disease

cAMP:

Cyclic adenosine monophosphate

COX:

Cyclooxygenase

ERK:

Extracellular signal-regulated kinases

GSH:

Glutathione

HO-1:

Heme oxygenase 1

HATs:

Histone acetyltransferases

IBD:

Inflammatory bowel disease

ICAM-1:

Intercellular adhesion molecule 1

IL:

Interleukin

Iso:

Isoorientin

JNK:

Jun N-terminal kinases

NQO1:

NADPH dehydrogenase quinone 1

NOX-4:

NADPH oxidase 4

NAD:

Nicotinamide adenine dinucleotide

Nrf2:

Nuclear factor erythroid 2-related factor 2

NF-κB:

Nuclear factor kappa B

NAC:

N-acetyl cysteine

PPAR-λ:

Peroxisome proliferator-activated receptor gamma

PDE4:

Phosphodiesterase 4

PI3K:

Phosphoinositide 3-kinases

ROS:

Reactive oxygen species

Scr:

Serum creatinine

Sirt1:

Sirtuin 1,

SOD:

Superoxide dismutase

TLR4:

Toll-like receptor4

TAC:

Total antioxidant capacity

TGF-β1:

Transformed growth factor-beta 1

TNF:

Tumor necrosis factor-α

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Acknowledgements

The authors are thankful to Mashhad University of Medical Science, Mashhad, Iran.

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Authors and Affiliations

  1. Department of Clinical Pharmacy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Simin Zare & Hedyieh Karbasforooshan

  2. University of South Florida College of Public Health, Tampa, FL, USA

    A. Wallace Hayes

  3. Institute for Integrative Toxicology, Michigan State University, East Lansing, MI, USA

    A. Wallace Hayes

  4. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Gholamreza Karimi

  5. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Gholamreza Karimi

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  1. Simin Zare
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  2. Hedyieh Karbasforooshan
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  4. Gholamreza Karimi
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GhK conceived and designed research; GhK and AWH revised and edited the manuscript; SZ and HK wrote the manuscript. All authors read and approved the final version of the manuscript.

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Correspondence to Gholamreza Karimi.

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Zare, S., Karbasforooshan, H., Hayes, A.W. et al. The modulation of sirtuins by natural compounds in the management of cisplatin-induced nephrotoxicity. Naunyn-Schmiedeberg's Arch Pharmacol 396, 693–703 (2023). https://doi.org/10.1007/s00210-022-02353-w

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