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Recent progresses in the pharmacological activities of caffeic acid phenethyl ester

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Abstract

The past decades have seen a growing interest in natural products. Caffeic acid phenethyl ester (CAPE), a flavonoid isolated from honeybee propolis, has shown multiple pharmacological potentials, including anti-cancer, anti-inflammatory, antioxidant, antibacterial, antifungal, and protective effects on nervous systems and multiple organs, since it was found as a potent nuclear factor κB (NF-κB) inhibitor. This review summarizes the advances in these beneficial effects of CAPE, as well as the underlying mechanisms, and proposes that CAPE offers an opportunity for developing therapeutics in multiple diseases. However, clinical trials on CAPE are necessary and encouraged to obtain certain clinically relevant conclusions.

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Funding

This work was supported by the National Natural Science Foundation of China [No.82000920] and the special fund for medical talents of Jilin Province, China [2019SRCJ022].

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Authors and Affiliations

  1. Jilin University, Changchun, 130021, China

    Lili Lv & Honghua Cui

  2. Department of Gastrointestinal Nutrition and Hernia Surgery, The Second Hospital of Jilin University, Changchun, 130041, China

    Zhiming Ma

  3. Eye Center, The Second Hospital of Jilin University, Changchun, 130041, China

    Xin Liu

  4. Jilin Provincial Key Laboratory on Molecular and Chemical Genetics, The Second Hospital of Jilin University, Changchun, 130041, China

    Longfei Yang

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  1. Lili Lv
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  2. Honghua Cui
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  4. Xin Liu
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L. L. and L. Y. conceived, researched, and wrote the manuscript. X. L. conceived the manuscript. H. C. and Z. M. provided critical revisions. All authors read and approved the manuscript. The authors declare that all data were generated in-house and that no paper mill was used.

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Lv, L., Cui, H., Ma, Z. et al. Recent progresses in the pharmacological activities of caffeic acid phenethyl ester. Naunyn-Schmiedeberg's Arch Pharmacol 394, 1327–1339 (2021). https://doi.org/10.1007/s00210-021-02054-w

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