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The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats

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Abstract

Sleep is involved in maintaining energy, regulating heat, and recovering tissues. Furthermore, proper cognitive functions need sufficient sleep. Many studies have revealed the impairment effect of sleep deprivation (SD) on cognitive functions including learning and memory. Alpha lipoic acid (ALA) is a potent free radical scavenger, biological antioxidant, and neuroprotective agent. Furthermore, ALA improves learning and memory performance, decreases oxidative stress, and enhances antioxidant biomarkers. In this study, we aimed to investigate the effect of ALA on social interaction and passive avoidance memories in sleep-deprived rats. Total sleep deprivation (TSD) apparatus was used to induce SD (for 24 h). Three-chamber paradigm test and shuttle box apparatus were used to evaluate social interaction and passive avoidance memory, respectively. Rats’ locomotor apparatus was used to assess locomotion. ALA was administered intraperitoneally at doses of 17 and 35 mg/kg for 3 consecutive days. The results showed SD impaired both types of memories. ALA at the dose of 35 mg/kg restored social interaction memory in sleep-deprived rats; while, at the dose of 17 mg/kg attenuated impairment effect of SD. Moreover, ALA at the dose of 35 mg/kg impaired passive avoidance memory in sham-SD rats and at both doses did not rescue passive avoidance memory in sleep-deprived rats. In conclusion, ALA showed impairment effect on passive avoidance memory, while improved social interaction memory in sleep-deprived rats.

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Authors and Affiliations

  1. Department of Bioscience and Biotechnology, Malek Ashtar University of Technology, P.O. Box: 13145-784, Tehran, Iran

    Maede Rezaie & Mohammad Ali Nasiri Khalili

  2. Cognitive and Neuroscience Research Center (CNRC), Amir-Almomenin Hospital, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran

    Mohammad Nasehi & Salar Vaseghi

  3. Department of Cognitive Neuroscience, Institute for Cognitive Science Studies (ICSS), Tehran, Iran

    Salar Vaseghi & Mohammad-Reza Zarrindast

  4. Department of Neuroscience, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad-Hossein Mohammadi-Mahdiabadi-Hasani

  5. Department of Pharmacology School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad-Reza Zarrindast

  6. Department of Neuroendocrinology, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad-Reza Zarrindast

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  1. Maede Rezaie
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  2. Mohammad Nasehi
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Contributions

M. Rezaie and MH. Mohammadi-Mahdiabadi-Hasani collected animal data. S. Vaseghi and M. Nasehi wrote and edited the manuscript and analyzed data. MR. Zarrindast and MA. Nasiri-Khalili designed the study. All the authors have approved the final manuscript. All data were generated in-house and that no paper mill was used.

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Rezaie, M., Nasehi, M., Vaseghi, S. et al. The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats. Naunyn-Schmiedeberg's Arch Pharmacol 393, 2081–2091 (2020). https://doi.org/10.1007/s00210-020-01916-z

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