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MiR-132-3p serves as a tumor suppressor in mantle cell lymphoma via directly targeting SOX11

Naunyn-Schmiedeberg's Archives of Pharmacology volume 393, pages 2197–2208 (2020)Cite this article

Abstract

Mantle cell lymphoma (MCL) is an uncommon type of non-Hodgkin’s lymphoma (NHL), comprising about 6% of NHL cases. SOX11 is a member of the group C of Sry-related high-mobility group (HMG) box (Sox) transcription factors, which is ubiquitously expressed in approximate 90% MCL cases. However, the underlying mechanisms of the SOX11 expression aberration are not fully unveiled. In the present study, we firstly observed that miR-132-3p was dramatically down-regulated in CD19+ lymphocytes isolated from peripheral blood mononuclear cells (PBMCs) of MCL patients. Subsequently, we found miR-132-3p exhibited potentials in clinical application, indicated by its negative association with high-risk clinical features. In terms of function, ectopic miR-132-3p aggravated cell apoptosis and arrested cell cycle in G0/G1, and then inhibited cell proliferation in vitro and tumor growth in vivo. Also, we identified miR-132-3p’s direct target, SOX11, in MCL cell lines, and loss-function of SOX11 blocked its inhibitory effect on cell proliferation in vitro. Collectively, our observations bring about a novel mechanism to explain the aberrant expression of SOX11 in MCL. Therefore, miR-132-3p may be a promising biomarker for the diagnosis of MCL.

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Funding

This work was supported by Grants from the Applied Basic Research Program of Xuzhou (Nos. KC19031). The funders had no role in study design, data collection and analysis, manuscript preparation, or decision to publish.

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Affiliations

  1. Department of Pathology, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, China

    Baoyu Wu, Jingyu Li & Han Wang

  2. Department of Dermatology, Xuzhou Children’s Hospital, Xuzhou Medical University, Xuzhou, Jiangsu, China

    Qian Wu

  3. Department of Pathology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China

    Hui Liu

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  1. Baoyu Wu
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  2. Jingyu Li
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Hui Liu designed research and wrote the paper; Baoyu Wu, Jingyu Li, Han Wang, and Qian Wu performed research and analyzed data.

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Correspondence to Hui Liu.

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Wu, B., Li, J., Wang, H. et al. MiR-132-3p serves as a tumor suppressor in mantle cell lymphoma via directly targeting SOX11. Naunyn-Schmiedeberg's Arch Pharmacol 393, 2197–2208 (2020). https://doi.org/10.1007/s00210-020-01834-0

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  • DOI: https://doi.org/10.1007/s00210-020-01834-0

Keywords

  • Mantle cell lymphoma (MCL)
  • miR-132-3p
  • SOX11