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Phytosynthesized metal oxide nanoparticles for pharmaceutical applications

  • Swetha Andra
  • Satheesh Kumar Balu
  • Jaison Jeevanandham
  • Murugesan Muthalagu
  • Manisha Vidyavathy
  • Yen San Chan
  • Michael Kobina DanquahEmail author
Review
  • 60 Downloads

Abstract

Developments in nanotechnology field, specifically, metal oxide nanoparticles have attracted the attention of researchers due to their unique sensing, electronic, drug delivery, catalysis, optoelectronics, cosmetics, and space applications. Physicochemical methods are used to fabricate nanosized metal oxides; however, drawbacks such as high cost and toxic chemical involvement prevail. Recent researches focus on synthesizing metal oxide nanoparticles through green chemistry which helps in avoiding the involvement of toxic chemicals in the synthesis process. Bacteria, fungi, and plants are the biological sources that are utilized for the green nanoparticle synthesis. Due to drawbacks such as tedious maintenance and the time needed for the nanoparticle formation, plant extracts are widely used in nanoparticle production. In addition, plants are available all over the world and phytosynthesized nanoparticles show comparatively less toxicity towards mammalian cells. Secondary metabolites including flavonoids, terpenoids, and saponins are present in plant extracts, and these are highly responsible for nanoparticle formation and reduction of toxicity. Hence, this article gives an overview of recent developments in the phytosynthesis of metal oxide nanoparticles and their toxic analysis in various cells and animal models. Also, their possible mechanism in normal and cancer cells, pharmaceutical applications, and their efficiency in disease treatment are also discussed.

Keywords

Pharmaceutical applications Cytotoxicity In vitro analysis Metal oxide nanoparticles Phytochemicals 

Notes

Acknowledgements

The authors would like to acknowledge their respective departments for their support in writing this article.

Author contribution

SA, SKB, and JJ wrote the manuscript which was revised and reviewed by MKD, YSC, MM, and MV. All authors read and approved the final version of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Textile TechnologyAnna UniversityChennaiIndia
  2. 2.Department of Ceramic TechnologyAnna UniversityChennaiIndia
  3. 3.Department of Chemical Engineering, Faculty of Engineering and ScienceCurtin UniversityMiriMalaysia
  4. 4.Chemical Engineering DepartmentUniversity of TennesseeChattanoogaUSA

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