Abstract
In order to calculated-measure the low-density lipoprotein cholesterol (LDL-C), the Friedewald formula is used. LDL can be calculated by Friedewald formula in this way: total cholesterol (TC) minus high-density lipoprotein (HDL)-cholesterol minus triglycerides (TG)/5 in milligrams per deciliter. In the article entitled “Agmatine protects rat liver from nicotine-induced hepatic damage via antioxidative, antiapoptotic, and antifibrotic pathways” published in the same journal (Vol, 389, pp. 1341–1351), LDL-C has been calculated in this way: LDL-C = TC − [HDL-C − (TG/5)] which is not in accordance with the Friedewald formula and thus the result is false. It may seem that this would be a typo but this could not be the case.
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References
Ahmadi SA, Boroumand MA, Gohari-Moghaddam K, Tajik P, Dibaj SM (2008) The impact of low serum triglyceride on LDL-cholesterol estimation. Arch Iran Med 11:318–321. https://www.ncbi.nlm.nih.gov/pubmed/18426324
El-Sherbeeny NA, Nader MA, Attia GM, Ateyya H (2016) Agmatine protects rat liver from nicotine-induced hepatic damage via antioxidative, antiapoptotic, and antifibrotic pathways. Naunyn Schmiedeberg’s Arch Pharmacol 389:1341–1351. https://doi.org/10.1007/s00210-016-1284-9. https://www.ncbi.nlm.nih.gov/pubmed/27638633
Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18:499–502. https://www.ncbi.nlm.nih.gov/pubmed/4337382
Nanda SK, Bharathy M, Dinakaran A, Ray L, Ravichandran K (2017) Correlation of Friedewald’s calculated low-density lipoprotein cholesterol levels with direct low-density lipoprotein cholesterol levels in a tertiary care hospital. Int J Appl Basic Med Res 7:57–62. https://doi.org/10.4103/2229-516X.198525. https://www.ncbi.nlm.nih.gov/pubmed/28251110
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Raeeszadeh, M., Beheshtipour, J. Letter to the Editor. Naunyn-Schmiedeberg's Arch Pharmacol 391, 669–670 (2018). https://doi.org/10.1007/s00210-018-1501-9
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DOI: https://doi.org/10.1007/s00210-018-1501-9