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Pharmacological investigations on mast cell stabilizer and histamine receptor antagonists in vincristine-induced neuropathic pain

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Abstract

The present study was designed to investigate the role of mast cells and mast cell-derived histamine in vincristine-induced neuropathic pain. Neuropathic pain was induced by administration of vincristine (100 μg/kg, i.p.) over a period of 10 days, with a break of 2 days, and pain behavioural estimations including pin prick, hot plate and acetone spray tests were performed to assess mechanical and heat hyperalgesia and cold allodynia, respectively, on days 0, 14 and 28. Mast cell stabilizer, sodium cromoglycate, H1 receptor antagonist promethazine and H2 receptor antagonist ranitidine were administered over a period of 12 days. Administration of vincristine resulted in significant development of heat and mechanical hyperalgesia as well as cold allodynia. Furthermore, the pain observed was markedly elevated on the 28th day in comparison to the 14th day. Administration of sodium cromoglycate, promethazine and ranitidine significantly reduced mechanical and heat hyperalgesia and cold allodynia. However, the pain-attenuating effects of ranitidine were significantly less as compared to sodium cromoglycate and promethazine, which suggests that H1 receptors play a more important role than H2 receptors in vincristine-induced neuropathic pain. It may be concluded that vincristine may degranulate mast cells to release inflammatory mediators, particularly histamine which may act through H1 (primarily H1) and H2 receptors to induce neuropathic pain.

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Acknowledgements

The authors are grateful to the Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India, for supporting this study and providing technical facilities for the work.

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, Patiala, 147002, India

    Amteshwar Singh Jaggi, Gunjanpreet Kaur & Nirmal Singh

  2. Akal College of Pharmacy and Technical Education, Mastuana Sahib, Sangrur, India

    Anjana Bali

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  1. Amteshwar Singh Jaggi
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  2. Gunjanpreet Kaur
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Contributions

Amteshwar Singh Jaggi: He conceived the idea, designed the project, participated in data collection and edited the manuscript.

GunjanPreet Kaur: She did the experimental work and collected the data.

Anjana Bali: She participated in the study design, data interpretation and revision of the manuscript.

Nirmal Singh: He participated in statistical analysis and writing of the manuscript.

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Correspondence to Amteshwar Singh Jaggi.

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Jaggi, A.S., Kaur, G., Bali, A. et al. Pharmacological investigations on mast cell stabilizer and histamine receptor antagonists in vincristine-induced neuropathic pain. Naunyn-Schmiedeberg's Arch Pharmacol 390, 1087–1096 (2017). https://doi.org/10.1007/s00210-017-1426-8

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