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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 386, Issue 9, pp 789–793 | Cite as

Intravenous infusion of ascorbic acid decreases serum histamine concentrations in patients with allergic and non-allergic diseases

  • Alexander F. Hagel
  • Christian M. Layritz
  • Wolfgang H. Hagel
  • Hans-Jürgen Hagel
  • Edith Hagel
  • Wolfgang Dauth
  • Jürgen Kressel
  • Tanja Regnet
  • Andreas Rosenberg
  • Markus F. Neurath
  • Gerhard J. Molderings
  • Martin RaithelEmail author
Original Article

Abstract

Histamine plays an important role in the development of symptoms in allergic, infectious, neoplastic and other diseases. Empirical findings have suggested beneficial effects of ascorbic acid supplementation in those diseases, and these effects are assumed to be related to a possible decrease in systemic histamine concentration. In the present study, we systematically investigated for the first time the effect of 7.5 g of intravenously administered ascorbic acid on serum histamine levels (as detected by ELISA) in 89 patients (19 with allergic and 70 with infectious diseases). When all patients were grouped together, there was a significant decline in histamine concentration from 0.83 to 0.57 ng/ml × m2 body surface area (BSA, p < 0.0001). The decrease in serum histamine concentration in patients with allergic diseases (1.36 to 0.69 ng/ml × m2 BSA, p = 0.0007) was greater than that in patients with infectious diseases (0.73 to 0.56 ng/ml × m2 BSA, p = 0.01). Furthermore, the decline in histamine concentration after ascorbic acid administration was positively correlated with the basal, i.e. pre-therapeutic, histamine concentration. Intravenous infusion of ascorbic acid clearly reduced histamine concentrations in serum, and may represent a therapeutic option in patients presenting with symptoms and diseases associated with pathologically increased histamine concentration.

Keywords

Allergic diseases Ascorbic acid Vitamin C Histamine concentration 

Notes

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Alexander F. Hagel
    • 1
  • Christian M. Layritz
    • 2
  • Wolfgang H. Hagel
    • 3
  • Hans-Jürgen Hagel
    • 3
  • Edith Hagel
    • 3
  • Wolfgang Dauth
    • 4
  • Jürgen Kressel
    • 1
  • Tanja Regnet
    • 3
  • Andreas Rosenberg
    • 5
  • Markus F. Neurath
    • 1
  • Gerhard J. Molderings
    • 6
  • Martin Raithel
    • 1
    Email author
  1. 1.Functional Tissue Diagnostics, Department of Medicine IUniversity ErlangenErlangenGermany
  2. 2.Department of Medicine IIUniversity ErlangenErlangenGermany
  3. 3.General Medicine PracticeSchwabachGermany
  4. 4.Institute of Employment ResearchNurembergGermany
  5. 5.General Medicine PracticeEckental-EckenhaidGermany
  6. 6.Institute of Human GeneticsUniversity Hospital of BonnBonnGermany

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