Abstract
Advanced glycation end products (AGEs), e.g., carboxymethyllysine (CML) or imidazolone are involved in several age-related disorders. Concerning their accumulation, the importance of hepatic and renal function is controversially discussed. To test whether impairment of hepatic or renal function will affect their accumulation, both AGEs have been measured in various populations, such as 52 patients with liver disease [viral hepatitis C without (n = 19) and with (n = 10) fatty liver; nonalcoholic fatty liver (n = 13), nonalcoholic steatohepatitis (n = 10)]. Serum concentrations of both AGEs have been compared to those in 20 healthy controls and 24 patients with moderate renal impairment (creatinine clearance 23–55 ml/min). Concerning CML (95% C.I. 803–1200 ng/ml), no differences between the various groups could be observed. Likewise, serum levels of imidazolone (95% C.I. 1.3–5.6 units) were similar in all populations. In conclusion, moderate impairment in hepatic or in renal function did not affect serum levels of CML and imidazolone. Apparently, any increase observed in severe cirrhosis or renal failure seems to be rather a consequence than a cause of both disorders.
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Acknowledgments
The secretarial help of Mrs. U. Hengemühle and the laboratory assistance of Mrs. S. Gutzeit and Mrs. M. Deckert are highly appreciated. We thank MicroCoat Biotechnologie GmbH for providing the imidazolone ELISA. The study was supported by the Doktor Robert Pfleger-Foundation Bamberg and the Robert Bosch Foundation, Germany.
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Butscheid, M., Schäfer, C., Brenner, S. et al. Unchanged serum levels of advanced glycation endproducts in patients with liver disease. Naunyn-Schmied Arch Pharmacol 375, 401–406 (2007). https://doi.org/10.1007/s00210-007-0171-9
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DOI: https://doi.org/10.1007/s00210-007-0171-9