Abstract
The effects of urotensin II (UII) on migration of human aortic smooth muscle cells (HASMCs) were investigated. UII (1–100 nM) significantly increased velocity of HASMC motility in a concentration-dependent manner. Stress-fiber formation and ERK (p44/p42) activity were also increased by UII. U0126 and PD 98059, MEK inhibitors, abolished the effects of UII on motility velocity and stress-fiber formation. These results suggest that UII enhances HASMC migration through activation of an ERK-dependent pathway.
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This work was supported by a grant for scientific research from the Grant of the Yamagata University 21st Century COE program.
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Matsusaka, S., Wakabayashi, I. Enhancement of vascular smooth muscle cell migration by urotensin II. Naunyn-Schmied Arch Pharmacol 373, 381–386 (2006). https://doi.org/10.1007/s00210-006-0086-x
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DOI: https://doi.org/10.1007/s00210-006-0086-x