Coffee consumption, metabolic syndrome and clinical severity of psoriasis: good or bad stuff?
- 269 Downloads
Despite the wide consumption of coffee, its anti-inflammatory effect on clinical severity of psoriasis is still debatable. The aim of this study was to evaluate the association between the coffee consumption and clinical severity of psoriasis in a sample of patients stratified according to the presence of the metabolic syndrome (MetS) and smoking. This cross-sectional case–control observational study was conducted on 221 treatment-naïve psoriatic patients. Lifestyle habits, anthropometric measures, clinical and biochemical evaluations were obtained. Clinical severity of psoriasis was assessed by Psoriasis Area and Severity Index (PASI) score. Data on energy caloric intake and coffee consumption were collected using a 7-day food diary record. The coffee consumption was analyzed as coffee intake (consumers and non-consumers) and daily servings (range 0–4 servings/day). Coffee consumers have a lower PASI score vs non-consumers (p < 0.001). The lowest PASI score and MetS prevalence were found in patients consuming 3 cups of coffee/day (p < 0.001), which was also the most common daily serving (34.8%), whereas the highest PASI score was found among those drinking ≥ 4 cups/day. Grouping the case patients according to smoking and MetS, the best odds of PASI score was observed in those drinking 3 cups of coffee per day and no smokers, after adjusting for total energy intake (OR 74.8; p < 0.001). As a novel finding, we reported a negative association between coffee intake, MetS prevalence and clinical severity of psoriasis. The evaluation of the anti-inflammatory effect of coffee on clinical severity of psoriasis, whose metabolic risk increases along with its clinical severity, could be of great importance from a public health perspective.
KeywordsCoffee consumption Clinical severity of psoriasis PASI score Metabolic syndrome Cigarette smoking Nutritionist
We would like to thank Dr. Daniela Laudisio for data retrieval.
The authors’ responsibilities were as follows: LB and SS: were responsible for the concept and design of the study and interpreted data and drafted the manuscript; GM, CDS, GA, MM, and AB: helped interpret the findings and contributed substantially to the writing of the manuscript; Only AF: conducted statistical analyses; GM and AC: provided a critical review of the manuscript. All authors contributed to and agreed on the final version of the manuscript.
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Compliance with ethical standards
Conflict of interest
The authors declare no conflicts of interest.
- Altieri B, Muscogiuri G, Barrea L, Mathieu C, Vallone CV, Mascitelli L, Bizzaro G, Altieri VM, Tirabassi G, Balercia G, Savastano S, Bizzaro N, Ronchi CL, Colao A, Pontecorvi A, Della Casa S (2017) Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept. Rev Endocr Metab Disord 18(3):335–346. https://doi.org/10.1007/s11154-016-9405-9 CrossRefPubMedGoogle Scholar
- Barrea L, Balato N, Di Somma C, Macchia PE, Napolitano M, Savanelli MC, Esposito K, Colao A, Savastano S (2015a) Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet?. J Transl Med 13:18. https://doi.org/10.1186/s12967-014-0372-1 CrossRefPubMedPubMedCentralGoogle Scholar
- Barrea L, Macchia PE, Tarantino G, Di Somma C, Pane E, Balato N, Napolitano M, Colao A, Savastano S (2015b) Nutrition: a key environmental dietary factor in clinical severity and cardio-metabolic risk in psoriatic male patients evaluated by 7-day food-frequency questionnaire. J Transl Med 13:303. https://doi.org/10.1186/s12967-015-0658-y CrossRefPubMedPubMedCentralGoogle Scholar
- Barrea L, Macchia PE, Di Somma C, Napolitano M, Balato A, Falco A, Savanelli MC, Balato N, Colao A, Savastano S (2016b) Bioelectrical phase angle and psoriasis: a novel association with psoriasis severity, quality of life and metabolic syndrome. J Transl Med 14(1):130. https://doi.org/10.1186/s12967-016-0889-6 CrossRefPubMedPubMedCentralGoogle Scholar
- Expert Panel on Detection (2001) Evaluation, and treatment of high blood cholesterol in adults: executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 285(19):2486–2497CrossRefGoogle Scholar
- Floegel A, Pischon T, Bergmann MM, Teucher B, Kaaks R, Boeing H (2012) Coffee consumption and risk of chronic disease in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Germany study. Am J Clin Nutr 95(4):901–908. https://doi.org/10.3945/ajcn.111.023648 CrossRefPubMedGoogle Scholar
- Grosso G, Godos J, Galvano F, Giovannucci EL (2017) Coffee, caffeine, and health outcomes: an umbrella review. Annu Rev Nutr 37:131–156. https://doi.org/10.1146/annurev-nutr-071816-064941 CrossRefPubMedGoogle Scholar
- Guida B, Napoleone A, Trio R, Nastasi A, Balato N, Laccetti R, Cataldi M (2014) Energy-restricted, n-3 polyunsaturated fatty acids-rich diet improves the clinical response to immuno-modulating drugs in obese patients with plaque-type psoriasis: a randomized control clinical trial. Clin Nutr 33(3):399–405. https://doi.org/10.1016/j.clnu.2013.09.010 CrossRefPubMedGoogle Scholar
- Hall S, Desbrow B, Anoopkumar-Dukie S, Davey AK, Arora D, McDermott C, Schubert MM, Perkins AV, Kiefel MJ, Grant GD (2015) A review of the bioactivity of coffee, caffeine and key coffee constituents on inflammatory responses linked to depression. Food Res Int 76(Pt 3):626–636. https://doi.org/10.1016/j.foodres.2015.07.027 CrossRefPubMedGoogle Scholar
- Hoidrup S, Andreasen AH, Osler M, Pedersen AN, Jorgensen LM, Jorgensen T, Schroll M, Heitmann BL (2002) Assessment of habitual energy and macronutrient intake in adults: comparison of a seven day food record with a dietary history interview. Eur J Clin Nutr 56(2):105–113. https://doi.org/10.1038/sj.ejcn.1601292 CrossRefPubMedGoogle Scholar
- International Coffee Council (2017). Trends in Coffee Consumption in Selected Importing Countries. http://www.ico.org/documents/icc-109-8e-trends-consumption.pdf. Accessed 13 Dec 2017
- National Center for Health Statistics (NCHS) (2011) Anthropometry Procedures Manual. National Health and Nutrition Examination Survey (NHANES). https://www.cdc.gov/nchs/data/nhanes/nhanes_11_12/Anthropometry_Procedures_Manual.pdf. Accessed 15 Nov 2017
- Shin HS, Satsu H, Bae MJ, Totsuka M, Shimizu M (2017) Catechol groups enable reactive oxygen species scavenging-mediated suppression of PKD-NFkappaB-IL-8 signaling pathway by chlorogenic and caffeic acids in human intestinal cells. Nutrients. https://doi.org/10.3390/nu9020165 CrossRefPubMedPubMedCentralGoogle Scholar
- Welch AA, McTaggart A, Mulligan AA, Luben R, Walker N, Khaw KT, Day NE, Bingham SA (2001) DINER (data into nutrients for epidemiological research)—a new data-entry program for nutritional analysis in the EPIC-Norfolk cohort and the 7-day diary method. Public Health Nutr 4(6):1253–1265CrossRefPubMedGoogle Scholar
- Wolters M (2006) The significance of diet and associated factors in psoriasis Hautarzt. 57(11):999–1004. https://doi.org/10.1007/s00105-006-1164-1
- World Health Organ Tech Rep Ser (2000) Obesity: preventing and managing the global epidemic. Rep WHO Consult 894:1–253Google Scholar