Archives of Toxicology

, Volume 91, Issue 9, pp 2965–2966 | Cite as

The current debate on cost burden by human exposure to endocrine disrupting chemicals

  • Hermann M. BoltEmail author

Recently, Gregory G. Bond from Northport, USA, and Daniel R. Dietrich from the University of Konstanz have contributed a comprehensive review about human cost burden of endocrine disrupting chemicals (Bond and Dietrich 2017). The authors critically discuss a recently published series of publications that claim that human exposure to endocrine disrupting chemicals cause substantial disease burdens and consequently cost society hundreds of billions of dollars per year (Trasande et al. 2015; Bellanger et al. 2015; Hauser et al. 2015; Legler et al. 2015; Hunt et al. 2016; Trasande et al. 2016; Attina et al. 2016). The largest fractions of these costs are based on the assumption that human exposure to organophosphate pesticides and brominated flame retardants cause ‘loss of IQ’.

The authors critically discuss the possible causal relationship and come to the conclusion that currently available evidence does not support a casual association with adverse neurodevelopmental and neurobehavioural outcomes in infants and children (Roth and Wilks 2014; Kim et al. 2014; Bond and Dietrich 2017). The main criticism includes incomplete control of confounding variables, weak and inconsistent findings in studies with small population sample sizes, uncertainties of exposure characterization and the lack of dose–response relationships. The authors conclude that the postulated causal relationship between endocrine disrupting chemical and disease burden is not supported by the available data. Therefore, the assigned disease burden costs lack scientific evidence (Bond and Dietrich 2017).

In recent years, endocrine active compounds have been a major focus in toxicological research (Hanioka et al. 2016; Van Esterik et al. 2016; Eisenbrand and Gelbke 2016; Niaz et al. 2015; Hengstler et al. 2011). Considering the high number of publications in this field with partially contradicting messages (Chen et al. 2015; Mansour et al. 2016; Wang et al. 2014; Harada et al. 2016; Dietrich and Hengstler 2016), systematic reviews on the weight of scientific evidence are of high value. In conclusion, currently not sufficient evidence is available to claim a causal relationship between environmental human exposure to organophosphates, as well as brominated flame retardants and reduced intelligence of children. For future studies in this field, it will be particularly important to study sufficiently large cohorts and control for possible confounding factors.


  1. Attina TM, Hauser R, Sathyanarayana S, Hunt PA, Bourguignon JP, Myers JP, DiGangi J, Zoeller RT, Trasande L (2016) Exposure to endocrine-disrupting chemicals in the USA: a population-based disease burden and cost analysis. Lancet Diabetes Endocrinol 4:996–1003. doi: 10.1016/S2213-8587(16)30275-3 CrossRefPubMedGoogle Scholar
  2. Bellanger M, Demeneix B, GrandjeanP Zoeller RT, Trasande L (2015) Neurobehavioral deficits, diseases, and associated costs of exposure to endocrine-disrupting chemicals in the European Union. J Clin Endocrinol Metab 100(4):1256–1266. doi: 10.1210/jc.2014-432 CrossRefPubMedPubMedCentralGoogle Scholar
  3. Bond GG, Dietrich DR (2017) Human cost burden of exposure to endocrine disrupting chemicals. A critical review. Arch Toxicol. doi: 10.1007/s00204-017-1985-y (Epub ahead of print) PubMedGoogle Scholar
  4. Chen ZJ, Yang XL, Liu H, Wei W, Zhang KS, Huang HB, Giesy JP, Liu HL, Du J, Wang HS (2015) Bisphenol A modulates colorectal cancer protein profile and promotes the metastasis via induction of epithelial to mesenchymal transitions. Arch Toxicol 89(8):1371–1381. doi: 10.1007/s00204-014-1301-z (Epub 2014 Aug 15) CrossRefPubMedGoogle Scholar
  5. Dietrich D, Hengstler JG (2016) From bisphenol A to bisphenol F and a ban of mustard due to chronic low-dose exposures? Arch Toxicol 90(2):489–491. doi: 10.1007/s00204-016-1671-5 (Epub 2016 Feb 2. No abstract available) CrossRefGoogle Scholar
  6. Eisenbrand G, Gelbke HP (2016) Assessing the potential impact on the thyroid axis of environmentally relevant food constituents/contaminants in humans. Arch Toxicol 90(8):1841–1857. doi: 10.1007/s00204-016-1735-6 (Epub 2016 May 11. Review. Erratum in: Arch Toxicol 90(8):1859) CrossRefPubMedGoogle Scholar
  7. Hanioka N, Isobe T, Kinashi Y, Tanaka-Kagawa T, Jinno H (2016) Hepatic and intestinal glucuronidation of mono(2-ethylhexyl) phthalate, an active metabolite of di(2-ethylhexyl) phthalate, in humans, dogs, rats, and mice: an in vitro analysis using microsomal fractions. Arch Toxicol 90(7):1651–1657. doi: 10.1007/s00204-015-1619-1 (Epub 2015 Oct 29) CrossRefPubMedGoogle Scholar
  8. Harada Y, Tanaka N, Ichikawa M, Kamijo Y, Sugiyama E, Gonzalez FJ, Aoyama T (2016) PPARα-dependent cholesterol/testosterone disruption in Leydig cells mediates 2,4-dichlorophenoxyacetic acid-induced testicular toxicity in mice. Arch Toxicol 90(12):3061–3071 (Epub 2016 Feb 2) CrossRefPubMedGoogle Scholar
  9. Hauser R, Skakkebaek NE, Hass U, Toppari J, Juul A, Andersson AM, Kortenkamp A, Heindel JJ, Trasande L (2015) Male reproductive disorders, diseases, and costs of exposure to endocrine-disrupting chemicals in the European Union. J Clin Endocrinol Metab 100(4):1267–1277. doi: 10.1210/jc.2014-4325 CrossRefPubMedPubMedCentralGoogle Scholar
  10. Hengstler JG, Foth H, Gebel T, Kramer PJ, Lilienblum W, Schweinfurth H, Völkel W, Wollin KM, Gundert-Remy U (2011) Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A. Crit Rev Toxicol 41(4):263–291. doi: 10.3109/10408444.2011.558487 (Review) CrossRefPubMedPubMedCentralGoogle Scholar
  11. Hunt PA, Sathyanarayana S, Fowler PA, Trasande L (2016) Female reproductive disorders, diseases, and costs of exposure to endocrine disrupting chemicals in the European Union. J Clin Endocrinol Metab. doi: 10.1210/jc.2015-2873 PubMedCentralGoogle Scholar
  12. Kim YR, Harden FA, Toms LM, Norman RE (2014) Health consequences of exposure to brominated flame retardants: a systematic review. Chemosphere 106:1–19. doi: 10.1016/j.chemosphere.2013.12.064 (Epub 2014 Feb 11) CrossRefPubMedGoogle Scholar
  13. Legler J, Fletcher T, Govarts E, Porta M, Blumberg B, Heindel JJ, Trasande L (2015) Obesity, diabetes, and associated costs of exposure to endocrine-disrupting chemicals in the European Union. J Clin Endocrinol Metab 100(4):1278–1288. doi: 10.1210/jc.2014-4326 CrossRefPubMedPubMedCentralGoogle Scholar
  14. Mansour A, Hosseini S, Larijani B, Mohajeri-Tehrani MR (2016) Nutrients as novel therapeutic approaches for metabolic disturbances in polycystic ovary syndrome. EXCLI J 15:551–564. doi: 10.17179/excli2016-422 (eCollection 2016. Review) PubMedPubMedCentralGoogle Scholar
  15. Niaz K, Bahadar H, Maqbool F, Abdollahi M (2015) A review of environmental and occupational exposure to xylene and its health concerns. EXCLI J 14:1167–1186. doi: 10.17179/excli2015-623 (eCollection 2015. Review) PubMedPubMedCentralGoogle Scholar
  16. Roth N, Wilks MF (2014) Neurodevelopmental and neurobehavioural effects of polybrominated and perfluorinated chemicals: a systematic review of the epidemiological literature using a quality assessment scheme. Toxicol Lett 230(2):271–281. doi: 10.1016/j.toxlet.2014.02.015 (Epub 2014 Feb 25) CrossRefPubMedGoogle Scholar
  17. Trasande L, Zoeller RT, Hass U, Kortenkamp A, Grandjean P, Myers JP, DiGangi J, Bellanger M, Hauser R, Legler J, Skakkebaek NE, Heindel JJ (2015) Estimating burden and disease costs of exposure to endocrine-disrupting chemicals in the European Union. J Clin Endocrinol Metab 100(4):1245–1255. doi: 10.1210/jc.2014-4324 CrossRefPubMedPubMedCentralGoogle Scholar
  18. Trasande L, Zoeller RT, Hass U, Kortenkamp A, Grandjean P, Myers JP, DiGangi J, Hunt PM, Rudel R, Sathyanarayana S, Bellanger M, Hauser R, Legler J, Skakkebaek NE, Heindel JJ (2016) Burden of disease and costs of exposure to endocrine disrupting chemicals in the European Union: an updated analysis. Andrology 4(4):565–572. doi: 10.1111/andr.12178 CrossRefPubMedPubMedCentralGoogle Scholar
  19. van Esterik JC, Bastos Sales L, Dollé ME, Håkansson H, Herlin M, Legler J, van der Ven LT (2016) Programming of metabolic effects in C57BL/6JxFVB mice by in utero and lactational exposure to perfluorooctanoic acid. Arch Toxicol 90(3):701–715. doi: 10.1007/s00204-015-1488-7 (Epub 2015 Apr 1) CrossRefPubMedGoogle Scholar
  20. Wang J, Dai S, Guo Y, Xie W, Zhai Y (2014) Biology of PXR: role in drug–hormone interactions. EXCLI J 13:728–739 (eCollection 2014. Review) PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.IfADo, Leibniz Research Centre for Working Environment and Human Factors at TU DortmundDortmundGermany

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