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Archives of Toxicology

, Volume 90, Issue 3, pp 493–511 | Cite as

Role of silver nanoparticles (AgNPs) on the cardiovascular system

  • Carmen GonzalezEmail author
  • Hector Rosas-Hernandez
  • Manuel Alejandro Ramirez-Lee
  • Samuel Salazar-García
  • Syed F. Ali
Review Article

Abstract

With the advent of nanotechnology, the use and applications of silver nanoparticles (AgNPs) have increased, both in consumer products as well as in medical devices. However, little is known about the effects of these nanoparticles on human health, more specific in the cardiovascular system, since this system represents an important route of action in terms of distribution, bioaccumulation and bioavailability of the different circulating substances in the bloodstream. A collection of studies have addressed the effects and applications of different kinds of AgNPs (shaped, sized, coated and functionalized) in several components of the cardiovascular system, such as endothelial cells, isolated vessels and organs as well as integrative animal models, trying to identify the underlying mechanisms involved in their actions, to understand their implication in the field of biomedicine. The purpose of the present review is to summarize the most relevant studies to date of AgNPs effects in the cardiovascular system and provide a broader picture of the potential toxic effects and exposure risks, which in turn will allow pointing out the directions of further research as well as new applications of these versatile nanomaterials.

Keywords

Silver nanoparticles Cardiovascular system Endothelium Blood vessels Toxicity 

Notes

Acknowledgments

The authors would like to acknowledge Mr. Daniel Alberto Maldonado-Ortega for his technical and artistic assistance during the realization of the manuscript.

Conflict of interest

The authors have no conflict of interest to declare.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Carmen Gonzalez
    • 1
    • 2
    Email author
  • Hector Rosas-Hernandez
    • 1
  • Manuel Alejandro Ramirez-Lee
    • 1
  • Samuel Salazar-García
    • 1
  • Syed F. Ali
    • 2
  1. 1.Facultad de Ciencias QuimicasUniversidad Autonoma de San Luis PotosiSan Luis PotosiMexico
  2. 2.Neurochemistry Laboratory, Division of NeurotoxicologyNational Center for Toxicological ResearchJeffersonUSA

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