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Role of silver nanoparticles (AgNPs) on the cardiovascular system

Archives of Toxicology volume 90, pages 493–511 (2016)Cite this article

Abstract

With the advent of nanotechnology, the use and applications of silver nanoparticles (AgNPs) have increased, both in consumer products as well as in medical devices. However, little is known about the effects of these nanoparticles on human health, more specific in the cardiovascular system, since this system represents an important route of action in terms of distribution, bioaccumulation and bioavailability of the different circulating substances in the bloodstream. A collection of studies have addressed the effects and applications of different kinds of AgNPs (shaped, sized, coated and functionalized) in several components of the cardiovascular system, such as endothelial cells, isolated vessels and organs as well as integrative animal models, trying to identify the underlying mechanisms involved in their actions, to understand their implication in the field of biomedicine. The purpose of the present review is to summarize the most relevant studies to date of AgNPs effects in the cardiovascular system and provide a broader picture of the potential toxic effects and exposure risks, which in turn will allow pointing out the directions of further research as well as new applications of these versatile nanomaterials.

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Acknowledgments

The authors would like to acknowledge Mr. Daniel Alberto Maldonado-Ortega for his technical and artistic assistance during the realization of the manuscript.

Conflict of interest

The authors have no conflict of interest to declare.

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Affiliations

  1. Facultad de Ciencias Quimicas, Universidad Autonoma de San Luis Potosi, Av. Manuel Nava Num. 6, Col. Universitaria, 78210, San Luis Potosi, SLP, Mexico

    Carmen Gonzalez, Hector Rosas-Hernandez, Manuel Alejandro Ramirez-Lee & Samuel Salazar-García

  2. Neurochemistry Laboratory, Division of Neurotoxicology, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR, USA

    Carmen Gonzalez & Syed F. Ali

Authors
  1. Carmen Gonzalez
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  2. Hector Rosas-Hernandez
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  3. Manuel Alejandro Ramirez-Lee
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  4. Samuel Salazar-García
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  5. Syed F. Ali
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Correspondence to Carmen Gonzalez.

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Gonzalez, C., Rosas-Hernandez, H., Ramirez-Lee, M.A. et al. Role of silver nanoparticles (AgNPs) on the cardiovascular system. Arch Toxicol 90, 493–511 (2016). https://doi.org/10.1007/s00204-014-1447-8

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  • DOI: https://doi.org/10.1007/s00204-014-1447-8

Keywords

  • Silver nanoparticles
  • Cardiovascular system
  • Endothelium
  • Blood vessels
  • Toxicity