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Exploring the potential of Aspergillus wentii: secondary metabolites and biological properties

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Abstract

Fungi are of considerable importance due to their capacity to biosynthesize various secondary metabolites with bioactive properties that draw high attention in new drug discovery with beneficial uses for improving human well-being and life quality. Aspergillus genus members are widespread and cosmopolitan species with varying economic significance in the fields of industry, medicine, and agriculture. Its species are renowned for their biosynthesis of secondary metabolites, characterized by both potent biological activity and structural novelty, making them a substantial reservoir for the development of new pharmaceuticals. The current work aimed at focusing on one species of this genus, Aspergillus wentii Wehmer, including its reported secondary metabolites in the period from 1951 to November 2023. A total of 97 compounds, including nitro-compounds, terpenoids, anthraquinones, xanthones, benzamides, and glucans. A summary of their bioactivities, as well as their biosynthesis was highlighted. Additionally, the reported applications of this fungus and its enzymes have been discussed. This review offers a useful reference that can direct future research into this fungus and its active metabolites, as well as their possible pharmacological and biotechnological applications.

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Data availability

The authors confirm that the data supporting the review are available within the article.

Abbreviations

A549:

Human lung adenocarcinoma epithelial cell line

AKR1C1:

Aldo–keto reductase family 1 member C1

AMP:

Adenosine monophosphate

BHT:

Butylated hydroxytoluene

CCK-8:

Cell counting kit-8

CD44:

Cell surface adhesion receptor

CD:

Circular dichroism

DFT:

Density functional theory

DPPH:

1,1-Diphenyl-2-picrylhydrazyl

EGFR:

Anti-epidermal growth factor receptor

ECD:

Electronic circular dichroism

ERK:

Extracellular signal-regulated kinase

GIAO:

Gauge-independent atomic orbital

GAP:

GTPase activating protein

GC%:

Guanine-cytosine content

H446:

Human small cell lung cancer cell line

HCC:

Hepatocellular carcinoma

HDAC:

Histone deacetylase

HEK293:

Human embryonic kidney cell

HepG2:

Human hepatocellular liver carcinoma cell line

HeLa:

Human cervical epitheloid carcinoma cell line

HPLC:

High-performance liquid chromatography

Huh-7:

Human male hepatoma cell line

IC50 :

Half-maximal inhibitory concentration

IZD:

Inhibition zone diameter

JNK:

C-Jun NH2-terminal kinase

L02:

Human liver cell line

LD50 :

Half maximal lethal concentration

Mb:

Megabases

MCF-7:

Human breast adenocarcinoma cell line

MDA-MB-231:

Human breast cancer cell line

MIC:

Minimum inhibitory concentrations

MS:

Mass spectrometry

MTT:

3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide

NAC:

N-Acetylcysteine

NCI-H460:

Human non-small cell lung cancer cell line

NMR:

Nuclear magnetic resonance

p38 MAPK:

P38 Mitogen-activated protein kinase

P53:

Tumor suppressor gene

ROS:

Reactive oxygen species

SCLC:

Small cell lung cancer cell line

SDGs:

Sustainable development goals

SiO2 CC:

Silica gel column chromatography

SMMC-7721:

Human hepatoma cell line

SPR:

Surface plasmon resonance

SW1990:

Human pancreatic cancer cell line

T-47D:

Human ductal breast epithelial tumor cell line

TLC:

Thin layer chromatography

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Faculty of Pharmacy, Umm Al-Qura University, 21955, Makkah, Saudi Arabia

    Bayan E. Ainousah

  2. Preparatory Year Program, Department of Chemistry, Batterjee Medical College, 21442, Jeddah, Saudi Arabia

    Sabrin R. M. Ibrahim

  3. Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut, 71526, Egypt

    Sabrin R. M. Ibrahim

  4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Gezira, Wad Medani, Gezira, Sudan

    Abdulrahim A. Alzain

  5. Faculty of Dentistry, British University, El Sherouk City, Suez Desert Road, Cairo, 11837, Egypt

    Shaimaa G. A. Mohamed

  6. Preparatory Year Program, Batterjee Medical College, 21442, Jeddah, Saudi Arabia

    Hazem G. A. Hussein

  7. Department of Pharmacognosy, Faculty of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia

    Ahmed Ashour

  8. Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt

    Ahmed Ashour

  9. Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, 21589, Jeddah, Saudi Arabia

    Hossam M. Abdallah & Gamal A. Mohamed

  10. Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt

    Hossam M. Abdallah

Authors
  1. Bayan E. Ainousah
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  2. Sabrin R. M. Ibrahim
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  3. Abdulrahim A. Alzain
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  4. Shaimaa G. A. Mohamed
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  5. Hazem G. A. Hussein
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  6. Ahmed Ashour
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  7. Hossam M. Abdallah
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  8. Gamal A. Mohamed
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Contributions

S.R.M.I., G.A.M., H.M.A., and A.A.A. contributed to the study`s conception and design. Data collection, literature search, and compilation were performed by S.G.A.M., B.E.A., and H.G.A.H. Preparation of data tables and generating structures by B.E.A., S.G.A.M., A.A., and H.G.A.H. Writing the original draft of the manuscript was done by S.R.M.I., A.A.A., G.A.M. and H.M.A. A.A. and B.E.A. reviewed and edited the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Sabrin R. M. Ibrahim.

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Communicated by Yusuf Akhter.

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Ainousah, B.E., Ibrahim, S.R.M., Alzain, A.A. et al. Exploring the potential of Aspergillus wentii: secondary metabolites and biological properties. Arch Microbiol 206, 216 (2024). https://doi.org/10.1007/s00203-024-03934-4

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  • DOI: https://doi.org/10.1007/s00203-024-03934-4

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