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The possible role of Helicobacter pylori in liver diseases

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Abstract

According to previous studies, Helicobacter pylori infection is associated with liver disease. In order to better understand the risk of acquiring various liver diseases, we reviewed current knowledge on the impact of H. pylori on the onset, intensification, and progression of various liver diseases caused by the infection of H. pylori. It has been estimated that between 50 and 90% of people worldwide have been infected with H. pylori. The bacterium is mostly responsible for inflamed gastric mucosa, ulcers, and cancers associated with the gastric mucosa. Through the active antioxidant system in H. pylori, the bacteria can neutralize free radicals by synthesizing VacA, a toxin that causes cell damage and apoptosis. Furthermore, there is a possibility that CagA genes may play a role in cancer development. People who have been infected with H. pylori are likely to develop lesions in the skin, the circulation system, and the pancreas. Moreover, transferring blood from the stomach may allow H. pylori to colonize the liver. The bacterium worsened liver function during autoimmune inflammation, toxic injury, chronic HCV infection, chronic HBV infection, and liver cirrhosis. Increasing portal pressure, hyperammonemia, and esophageal varices may be associated with H pylori infection. As a result, it is crucial to diagnose and treat this infection in patients with H. pylori.

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The datasets used and analyzed during the current study are available from published articles.

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Acknowledgements

Studies have been done. Thanks to Qazvin University of Medical Sciences for providing the research situation for us to design this study, search, collect data, analyze, and write the manuscript.

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Authors and Affiliations

  1. Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran

    Mahnaz Mohammadi, Adeleh Attar, Maryam Mohammadbeigi, Amir Peymani, Shahin Bolori & Fatemeh Fardsanei

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  1. Mahnaz Mohammadi
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  2. Adeleh Attar
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  3. Maryam Mohammadbeigi
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  4. Amir Peymani
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  5. Shahin Bolori
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  6. Fatemeh Fardsanei
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All authors write and reviewed the manuscript

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Correspondence to Fatemeh Fardsanei.

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Communicated by Yusuf Akhter.

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Mohammadi, M., Attar, A., Mohammadbeigi, M. et al. The possible role of Helicobacter pylori in liver diseases. Arch Microbiol 205, 281 (2023). https://doi.org/10.1007/s00203-023-03602-z

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