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An extended catalogue of ncRNAs in Streptomyces coelicolor reporting abundant tmRNA, RNase-P RNA and RNA fragments derived from pre-ribosomal RNA leader sequences

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Streptomyces coelicolor is a model organism for studying streptomycetes. This genus possesses relevant medical and economical roles, because it produces many biologically active metabolites of pharmaceutical interest, including the majority of commercialized antibiotics. In this bioinformatic study, the transcriptome of S. coelicolor has been analyzed to identify novel RNA species and quantify the expression of both annotated and novel transcripts in solid and liquid growth medium cultures at different times. The major characteristics disclosed in this study are: (i) the diffuse antisense transcription; (ii) the great abundance of transfer-messenger RNAs (tmRNA); (iii) the abundance of rnpB transcripts, paramount for the RNase-P complex; and (iv) the presence of abundant fragments derived from pre-ribosomal RNA leader sequences of unknown biological function. Overall, this study extends the catalogue of ncRNAs in S. coelicolor and suggests an important role of non-coding transcription in the regulation of biologically active molecule production.

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WA, and CC acknowledge support by Regione Siciliana, through the PO FESR action 1.1.5, project OBIND N.086202000366—CUP G29J18000700007


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SIG, VB and WA developed methodology and performed investigations; CC, GG and WA wrote the paper; WA and GG performed work conceptualization; GG and CC provided resources; WA performed project administration.

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Correspondence to Walter Arancio.

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Communicated by Erko Stackebrandt.

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Arancio, W., Genovese, S.I., Benfante, V. et al. An extended catalogue of ncRNAs in Streptomyces coelicolor reporting abundant tmRNA, RNase-P RNA and RNA fragments derived from pre-ribosomal RNA leader sequences. Arch Microbiol 204, 582 (2022).

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