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A review on the effect of gut microbiota on metabolic diseases

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Abstract

Human gut microbiota are a huge and complex microbial community, which is recognized to play a significant role in regulating host metabolism. However, the destruction of gut microbiota leads to the pathological response of host, and thus results in a variety of metabolic diseases. This article gives a brief review of research progress on gut microbiota and some main metabolic diseases, including osteoporosis, obesity, type 2 diabetes, non-alcoholic fatty liver, and hypertension, with a specific focus on the effect of gut microbiota on diseases’ occurrence and development. In addition, this review article also shows some case studies on the regulation of gut microbiota by new means, such as fecal microbiota transplantation and oral probiotics. Although gut microbiota are considered as a promising novel target for the treatment of metabolic diseases, it is also necessary to encourage further studies to provide more valuable data for guiding the application of gut microbiota on disease therapy in future.

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Acknowledgements

We acknowledge the authors for their continued hard work.

Funding

This work was financially supported by the National Natural Science Foundation of China (32101368), Natural Science Foundation of Hunan Province (2020JJ5709), and Science and Technology Plan Project for Natural Resources of Hunan Province (2021-50).

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Author notes

  1. Qiwei Shi and Lingli Dai contributed equally to this work.

Authors and Affiliations

  1. Department of Occupational and Environmental Health, Xiangya School of Public Health, Central South University, Changsha, China

    Qiwei Shi, Qi Zhao & Xian Zhang

  2. Department of Gynecology, Third Xiangya Hospital, Central South University, Changsha, China

    Lingli Dai

  3. Hunan Provincial Key Laboratory of Clinical Epidemiology, Central South University, Changsha, China

    Xian Zhang

Authors
  1. Qiwei Shi
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  2. Lingli Dai
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  3. Qi Zhao
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  4. Xian Zhang
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Contributions

QS and LD contributed to writing the initial draft. QZ contributed to drawing the charts. XZ contributed to reviewing and revising the paper, and the financial support for this work.

Corresponding author

Correspondence to Xian Zhang.

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Communicated by Erko Stackebrandt.

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Shi, Q., Dai, L., Zhao, Q. et al. A review on the effect of gut microbiota on metabolic diseases. Arch Microbiol 204, 192 (2022). https://doi.org/10.1007/s00203-022-02802-3

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  • DOI: https://doi.org/10.1007/s00203-022-02802-3

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