Archives of Microbiology

, Volume 199, Issue 2, pp 223–230 | Cite as

Genomic and transcriptome analysis of triclosan response of a multidrug-resistant Acinetobacter baumannii strain, MDR-ZJ06

  • Borui Pi
  • Dongliang Yu
  • Xiaoting Hua
  • Zhi Ruan
  • Yunsong YuEmail author
Original Paper


During the last decade, an increasing amount of attention has focused on the potential threat of triclosan to both the human body and environmental ecology. However, the role of triclosan in the development of drug resistance and cross resistance is still in dispute ascribed to largely unknown of triclosan resistance mechanism. In this work, Acinetobacter baumannii MDR-ZJ06, a multidrug-resistant strain, was induced by triclosan, and the genomic variation and transcriptional levels were investigated, respectively. The comparative transcriptomic analysis found that several general protective mechanisms were enhanced under the triclosan condition, including responses to reactive oxygen species and cell membrane damage. Meanwhile, all of the detected fifteen single nucleotide polymorphisms were not directly associated triclosan tolerance. In summary, this work revealed the crucial role of the general stress response in A. baumannii under a triclosan stress condition, which informs a more comprehensive understanding of the role of triclosan in the spread of drug-resistant bacteria.


Acinetobacter baumannii Reactive oxygen species FabI RNA-seq Multidrug resistance 



This work was supported by the National Natural Science Foundation of China (81201327).

Compliance with ethical standards

Conflict of interest

None declared.

Supplementary material

203_2016_1295_MOESM1_ESM.doc (32 kb)
Supplementary material 1 (DOC 32 kb)


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Borui Pi
    • 1
  • Dongliang Yu
    • 2
  • Xiaoting Hua
    • 1
  • Zhi Ruan
    • 1
  • Yunsong Yu
    • 1
    Email author
  1. 1.Department of Infectious Diseases, Sir Run Run Shaw Hospital, College of MedicineZhejiang UniversityHangzhouChina
  2. 2.College of Life and Environmental SciencesHangzhou Normal UniversityHangzhouChina

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