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Archives of Microbiology

, Volume 199, Issue 2, pp 215–222 | Cite as

ANTISTAPHYBASE: database of antimicrobial peptides (AMPs) and essential oils (EOs) against methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus aureus

  • Abdelmajid ZouhirEmail author
  • Malek Taieb
  • Mohamed Ashraf Lamine
  • Ammar Cherif
  • Taoufik Jridi
  • Basma Mahjoubi
  • Sarra Mbarek
  • Ismail Fliss
  • Adel Nefzi
  • Khaled Sebei
  • Jeannette Ben Hamida
Original Paper

Abstract

Staphylococcus aureus and methicillin-resistant S. aureus are major pathogens. The antimicrobial peptides and essential oils (EOs) display narrow- or broad-spectrum activity against bacteria including these strains. A centralized resource, such as a database, designed specifically for anti-S. aureus/anti-methicillin-resistant S. aureus antimicrobial peptides and EOs is therefore needed to facilitate the comprehensive investigation of their structure/activity associations and combinations. The database ANTISTAPHYBASE is created to facilitate access to important information on antimicrobial peptides and essential peptides against methicillin-resistant S. aureus and S. aureus. At the moment, the database contains 596 sequences of antimicrobial peptides produced by diverse organisms and 287 essential oil records. It permits a quick and easy search of peptides based on their activity as well as their general, physicochemical properties and literature data. These data are very useful to perform further bioinformatic or chemometric analysis and would certainly be useful for the development of new drugs for medical use. The ANTISTAPHYBASE database is freely available at: https://www.antistaphybase.com/.

Keywords

Anti-MRSA peptides Anti-MRSA EOs Anti-S. aureus peptides Anti-S. aureus EOs 

Notes

Acknowledgments

Authors thank Dr. Sadok Mokthar for their critical reading of the manuscript and Mr Samir Borji for his contributions to the database-related work described here. We thank Mme Aziza Cherif  and Mr Houcine Zouheir for their support.

Compliance with ethical standards

Conflict of interest

The authors report that they have no conflict of interest.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Abdelmajid Zouhir
    • 1
    • 2
    Email author
  • Malek Taieb
    • 3
  • Mohamed Ashraf Lamine
    • 1
    • 2
  • Ammar Cherif
    • 4
  • Taoufik Jridi
    • 1
    • 2
  • Basma Mahjoubi
    • 1
    • 2
  • Sarra Mbarek
    • 1
    • 2
  • Ismail Fliss
    • 5
  • Adel Nefzi
    • 6
  • Khaled Sebei
    • 1
    • 2
  • Jeannette Ben Hamida
    • 1
    • 2
  1. 1.Nutraceuticals and Functional Proteomics Potential of Biodiversity in TunisiaUniversity of Tunis ELMANARTunisTunisia
  2. 2.Research Unit at Institute of Applied Biological Sciences Tunis (ISSBAT)TunisTunisia
  3. 3.Faculty of Sciences of GabesUniversity of gabesGabèsTunisia
  4. 4.Faculty of Sciences of TunisUniversité of El Manar TunisTunisia
  5. 5.Institut des Nutraceutiques et des Aliments Fonctionnels (INAF)Université LavalQuebecCanada
  6. 6.Torrey Pines Institute for Molecular StudiesPort St. LucieUSA

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