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DXA-based bone strain index in normocalcemic primary hyperparathyroidism

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Abstract

Summary

The trabecular and cortical bone assessed by bone strain index seems not to be significantly affected in NHPT.

Introduction

The natural history and bone involvement of normocalcemic hyperparathyroidism (NHPT) are not fully clarified yet. The bone strain index (BSI) is a deformation index based on the finite element method and can be applied to DXA scans. In this study, we aim to assess BSI in subjects with NHPT.

Method

A case–control study included 170 subjects: 40 subjects with NHPT, 50 subjects with primary hypercalcemic hyperparathyroidism (PHPT), and 80 controls (age- and sex-matched with the NPTH group).

Results

Lumbar spine (LS) bone mineral density (BMD), femoral neck (FN) BMD, total hip (TH) BMD, and TBS were similar between NHPT and both PHPT and controls. FN-BSI was lower in NHPT compared to PHPT (1.52 ± 0.31 vs 1.72 ± 0.42 p = 0.031) while there were no differences between NHPT and controls. TH-BSI was lower in NHPT compared to PHPT (1.36 ± 0.23 vs 1.52 ± 0.34, p = 0.030), while there were no differences between NHPT and controls. LS-BSI was not different between NHPT and both PHPT and controls.

Conclusion

The trabecular and cortical bones assessed by BSI seem not to be significantly impaired in NHPT. Further prospective studies are needed to confirm these findings and to give an insight into the natural history of NHPT to improve knowledge and management of this condition.

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Data Availability

The data that support the findings of this study are available from the corresponding author (GT), upon reasonable request.

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Author information

Author notes

  1. Gaia Tabacco and Anda Mihaela Naciu contributed equally to the study.

Authors and Affiliations

  1. Unit of Metabolic Bone and Thyroid Diseases, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy

    Gaia Tabacco, Anda Mihaela Naciu, Nicola Napoli & Andrea Palermo

  2. Unit of Endocrinology and Diabetes, Campus Bio-Medico University of Rome, Rome, Italy

    Gaia Tabacco, Anda Mihaela Naciu, Nicola Napoli & Andrea Palermo

  3. IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

    Carmelo Messina

  4. Dipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Milan, Italy

    Carmelo Messina

  5. School of Nursing, Clinical Department of Medical, Surgical and Health Sciences, University of Trieste, Trieste, Italy

    Gianfranco Sanson

  6. Tecnologie Avanzate, Torino, Italy

    Luca Rinaudo

  7. UOS Malattie Metaboliche, Santa Maria Goretti Hospital, Latina, Italy

    Roberto Cesareo

  8. Unit of Endocrinology and Metabolic Diseases, CTO A. Alesini Hospital, University Tor Vergata, Rome, Italy

    Stefania Falcone

  9. Bone Metabolic Unit, Casa di Cura la Madonnina, Milano, Italy

    Fabio Massimo Ulivieri

Authors
  1. Gaia Tabacco
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  2. Anda Mihaela Naciu
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  3. Carmelo Messina
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  4. Gianfranco Sanson
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  5. Luca Rinaudo
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  6. Roberto Cesareo
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  7. Stefania Falcone
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  8. Nicola Napoli
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  9. Fabio Massimo Ulivieri
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  10. Andrea Palermo
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Contributions

Study design: GT, AMN, and AP; data collection: GT, AMN, GS, SF, and AP; data analysis: GT, AMN, CM, GS, LR, and AP; data interpretation: GT, AMN, CM, GS, LR, RC, FMU, and AP; drafting manuscript: GT, AMN, GS, FMU, and AP; revising manuscript content: GT, AMN, CM, LR, GS, RC, SF, NN, FMU, and AP; approving the final version of manuscript: GT, AMN, CM, LR, GS, RC, SF, NN, FMU, and AP. All authors take responsibility for the integrity of the data analysis.

Corresponding author

Correspondence to Gaia Tabacco.

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Conflict of interest

C. Messina, G. Sanson, S. Falcone, and F.M. Ulivieri disclosed no conflict of interest; G Tabacco disclosed lecture fees from Amgen; L. Rinaudo was put in charge of the BSI project by Tecnologie Avanzate s.r.l.; A.M. Naciu and R. Cesareo disclosed lecture fees from Amgen and Bruno Farmaceutici; N. Napoli disclosed consultant for Lilly, Abiogen, and UCB; A. Palermo disclosed lecture fees from Amgen and Abiogen.

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Tabacco, G., Naciu, A.M., Messina, C. et al. DXA-based bone strain index in normocalcemic primary hyperparathyroidism. Osteoporos Int 34, 999–1003 (2023). https://doi.org/10.1007/s00198-023-06669-y

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  • DOI: https://doi.org/10.1007/s00198-023-06669-y

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