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Osteogenesis imperfecta and rheumatoid arthritis: connective issues

  • Letter to the Editor
  • Published:
Osteoporosis International Aims and scope Submit manuscript

A Letter to the Editor to this article was published on 19 August 2022

Abstract

The coexistence of osteogenesis imperfecta and inflammatory arthritis has been very rarely described. Nevertheless, systemic inflammation has been found in osteogenesis imperfecta. The COL1A1 mutations may affect collagen synthesis as well as post-translational modifications, extracellular matrix interactions, and receptor-mediated signaling. Major collagen binding ligands forming the interactome, such as cytokines, cell adhesion molecules, matrix metalloproteinases, proteoglycans, and other molecules, are autoimmunity targets involved in rheumatoid arthritis pathogenesis. Cross-talk between bone remodeling and inflammatory pathways involving osteoclasts is important in osteogenesis imperfecta and rheumatoid arthritis. In osteogenesis imperfecta, the structural abnormalities and repeated traumatism, including fractures, could activate locally the innate immunity and trigger arthritis, similar to post-traumatic arthritis. Currently, the therapy of osteogenesis imperfecta is a suboptimally met need. Understanding the complex putative pathogenic links between osteogenesis imperfecta and inflammatory arthritis could hopefully lead to new therapeutic targets. Raising awareness regarding a possible association between osteogenesis imperfecta and arthritis could help improve the quality of life in these patients.

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Abbreviations

ECM:

Extracellular matrix

ER:

Endoplasmic reticulum

IL-1:

Interleukin-1

MLBR:

Major ligand binding region

OI:

Osteogenesis imperfecta

RA:

Rheumatoid arthritis

TNFα:

Tumor necrosis factor α

TREM-1:

Triggering receptors expressed on myeloid cells-1

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Author information

Authors and Affiliations

  1. Rheumatology Dept, Emergency Clinical County Hospital Cluj, 2-4 Clinicilor St, 400006, Cluj-Napoca-Napoca, Romania

    Laura Otilia Damian

  2. CMI Reumatologie Dr Damian, 6-8 Petru Maior St, 400002, Cluj-Napoca-Napoca, Romania

    Laura Otilia Damian

  3. Department of Medical Genetics, Emergency Pediatric Hospital, Cluj-Napoca-Napoca, Romania

    Diana Miclea

  4. Department of Molecular Sciences, University of Medicine and Pharmacy “Iuliu Hatieganu, ” 6 Pasteur St, 400349, Cluj-Napoca-Napoca, Romania

    Diana Miclea, Romana Vulturar & Alexandra Crăciun

  5. Cognitive Neuroscience Laboratory, University Babes-Bolyai, 30 Fântânele St, 400294, Cluj-Napoca-Napoca, Romania

    Romana Vulturar

Authors
  1. Laura Otilia Damian
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  2. Diana Miclea
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  4. Alexandra Crăciun
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Contributions

LD has drafted the manuscript and DM, RV, and AC have critically revised it for important intellectual content. All authors have approved the final version of the submission.

Corresponding author

Correspondence to Laura Otilia Damian.

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Damian, L.O., Miclea, D., Vulturar, R. et al. Osteogenesis imperfecta and rheumatoid arthritis: connective issues. Osteoporos Int 33, 2237–2239 (2022). https://doi.org/10.1007/s00198-022-06530-8

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  • DOI: https://doi.org/10.1007/s00198-022-06530-8

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