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Distal radius and tibia bone microarchitecture impairment in female patients with diffuse systemic sclerosis

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Abstract

Summary

Radius and tibia bone microarchitecture, analyzed through a high-resolution peripheral quantitative computed tomography, were significantly impaired in female patients with diffuse systemic sclerosis compared with healthy controls. Acroosteolysis, quality of life-grip strength, hand disability, and disease duration were significantly associated with this bone deterioration.

Introduction

The effect of diffuse systemic sclerosis (dSSc) on the bone is not completely understood. The objective of this study was to analyze the volumetric bone mineral density (vBMD), microarchitecture, and biomechanical parameters at the distal radius and tibia using high-resolution peripheral quantitative computed tomography (HR-pQCT, XtremeCT) in female patients with dSSc and identify clinical and laboratory variables associated with these parameters.

Methods

Thirty-eight women with dSSc and 76 healthy controls were submitted to HR-pQCT at the distal radius and tibia. Clinical and laboratory findings, bone mineral density(BMD), nailfold capillaroscopy (NC), total passive range of motion(ROM), and quality of life (health assessment questionnaire—HAQ) were associated with HR-pQCT (Scanco Medical AG, Brüttisellen, Switzerland) parameters. Multiple linear regression models adjusted for clinical and laboratory variables, ROM and HAQ, were performed.

Results

Density, microarchitecture, and biomechanical parameters at the distal radius and tibia were significantly impaired in dSSc patients compared with healthy controls (p < 0.001). Multiple linear regression models showed that lower trabecular density (Tb.vBMD) (radius R2 = 0.561, p = 0.002; and tibia R2 = 0.533, p = 0.005), and lower trabecular number (Tb.N) (tibia R2 = 0.533, p = 0.005) were significantly associated with acroosteolysis. Higher trabecular separation (Tb.Sp) was associated with disease duration and higher HAQ-grip strength (radius R2 = 0.489, p = 0.013), while cortical density (Ct.vBMD) was associated with ROM (radius R2 = 0.294, p = 0.002).

Conclusion

Bone microarchitecture in patients with dSSc, analyzed through HR-pQCT, showed impairment of trabecular and cortical bone at distal radius and tibia. Variables associated with hand involvement (acroosteolysis, quality of life-grip strength, and ROM) and disease duration may be considered prognostic factors of this bone impairment.

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Financial support

Marília M. Sampaio-Barros is a recipient of a Post-Doctoral Research Grant from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Ministério da Educação (MEC). Percival D. Sampaio-Barros and Rosa Maria R. Pereira were recipients of a research grant from Federico Foundation (Switzerland) and grant from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq # 472754/2013-0 to RMRP).

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Authors and Affiliations

  1. Bone Metabolism Laboratory, Rheumatology Division, Hospital das Clinicas HCFMUSP, Universidade de Sao Paulo, Av. Dr. Arnaldo, 455, 3° andar, sala 3193, São Paulo, SP, 01246-903, Brazil

    M. M. Sampaio-Barros, J. C. Alvarenga, L. Takayama, A. P. L. Assad, P. D. Sampaio-Barros & R. M. R. Pereira

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  1. M. M. Sampaio-Barros
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  2. J. C. Alvarenga
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Sampaio-Barros, M., Alvarenga, J., Takayama, L. et al. Distal radius and tibia bone microarchitecture impairment in female patients with diffuse systemic sclerosis. Osteoporos Int 30, 1679–1691 (2019). https://doi.org/10.1007/s00198-019-04965-0

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