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Relationship of American Indian blood quantum with osteoporosis risk: a cross-sectional study of American Indian women in Oklahoma

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Abstract

Summary

Information regarding the prevalence and risk of osteoporosis among American Indian (AI) women is limited. This study showed that with increasing AI blood quantum, the prevalence of osteoporosis at the hip based on BMD T-scores decreased and this appeared to be independent of other risk factors.

Introduction

This study was designed to investigate the effects of AI blood quantum (BQ) on osteoporosis prevalence and risk in a cohort of AI women in Oklahoma.

Methods

Women (n = 301), aged 50 years and older, were recruited to participate in the Oklahoma American Indian Women’s Osteoporosis Study. Baseline bone density, fracture history, bone biochemical markers, and potential risk factors were assessed. Participants were stratified by AI BQ into BQ1 ≤ 25%, BQ2 = 25–49%, BQ3 = 50–74%, and BQ4 = 75–100%. The effects of BQ on the prevalence and risk of osteoporosis were evaluated.

Results

Based on T-scores, one in approximately eight women in the study was osteoporotic at one or more sites. The prevalence of osteoporosis decreased (p < 0.05) with increasing BQ, especially at the hip, trochanteric, and intertrochanter regions. No differences in bone-specific alkaline phosphatase and C-telopeptide were observed across BQ that could account for the differences in bone density. 25-OH vitamin D decreased with increasing BQ, but mean for each BQ1–4 was > 40 ng/mL. Fracture history did not differ across BQ, and though 52% of the population consumed less than the RDA for calcium, no effect of BQ was observed.

Conclusions

In this cohort of women who identified as AI, greater Indian BQ was associated with a decrease in the prevalence of osteoporosis.

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Acknowledgements

This study was supported by the NIH/NCRR-funded (M01-RR14467) General Clinical Research Center, NIH/NCRR (P20 RR 024215)-funded Oklahoma Shared Clinical and Translational Resources at the University of Oklahoma Health Sciences Center, and the Oklahoma Agriculture Experiment Station (OKLO2690) at Oklahoma State University.

Author information

Authors and Affiliations

  1. Department of Nutritional Sciences, Oklahoma State University, 420 Human Sciences, Stillwater, OK, 74078, USA

    B. J. Smith & J. Hermann

  2. Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    M. J. Leyva & L. D. Stephens

  3. Department of Pediatrics CMRI Metabolic Research Program, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    C. E. Aston

  4. Department of Statistics, College of Arts and Sciences, Oklahoma State University, Stillwater, OK, USA

    M. Payton

  5. Section of Endocrinology and Diabetes, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    M. Z. Baker

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  1. B. J. Smith
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  5. J. Hermann
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Correspondence to B. J. Smith.

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Statement of human rights

This study was approved by OUHSC IRB (#3040) in agreement with Oklahoma State University (IRB #HE0840) and IHS (IRB #P-07-03-OK). All procedures have been performed in accordance with the ethical standards as laid described in the 1964 Declaration of Helsinki and its subsequent amendments.

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Smith, B.J., Leyva, M.J., Stephens, L.D. et al. Relationship of American Indian blood quantum with osteoporosis risk: a cross-sectional study of American Indian women in Oklahoma. Osteoporos Int 29, 2251–2260 (2018). https://doi.org/10.1007/s00198-018-4594-6

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  • DOI: https://doi.org/10.1007/s00198-018-4594-6

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