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Poor medication adherence to bisphosphonates and high self-perception of aging in elderly female patients with osteoporosis

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Abstract

Summary

Non-adherence to bisphosphonates exposes the elderly female osteoporosis patients to an increased risk of fracture. This was one of the first studies to explore the relationship between medication adherence and self-perception of aging. Feelings of lacking control and expectations for negative events, beliefs of illness’s chronic duration nature, and its linkage with aging were associated with of poor medication adherence.

Introduction

To examine the relationship between medication adherence to bisphosphonates and self-perception of aging in elderly female patients with osteoporosis.

Methods

This was a cross-sectional survey. A convenience sample of 245 elderly female patients with osteoporosis prescribed regular oral bisphosphonate therapy was recruited from three tertiary hospitals in China. Sociodemographic and osteoporosis-related data, Morisky Medication Adherence Scale-8 (MMAS-8) and Aging Perceptions Questionnaire (APQ) data were collected.

Results

Mean adherence score measured by MMAS-8 was 4.46(SD = 1.91; range, 0.25–7.00). Percentages of good and poor adherence were 28.6 and 71.4 %, which showed a poor medication adherence. Six domains of APQ statistically significantly associated with medication adherence. Interestingly, with control of age, educational status, marital status, and symptoms accompanying osteoporosis as covariates in the multivariate linear regression model, the effects of three domains disappeared. Significantly, worse adherence was observed in those patients who had higher feelings of lack of control, more expectations for negative events, more beliefs of osteoporosis’s chronic duration nature and its linkage with aging.

Conclusions

We conclude that feelings of lacking control, expectations for negative events, beliefs of illness’s chronic duration nature, and its linkage with aging were associated with poor medication adherence in elderly female patients with osteoporosis. Concerns about self-perception of aging need to be addressed in order to improve medication adherence.

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Acknowledgments

We wish to thank the 245 female elderly patients with osteoporosis who have given their time to take part in the questionnaire interview, Miss Xiyue Zhang for her contribution to the development and pilot testing of the questionnaire in this study, Mr. Thomas Xue, Ms. Jing Wang, and Miss Ivy Liu for their modification on overall syntax including tense use of the manuscript.

Author information

Authors and Affiliations

  1. Peking University School of Nursing, No. 38 Xueyuan Road, Haidian, Beijing, 100191, China

    X. Wu

  2. General Surgery Department, Beijing Hospital, No. 1 Dongdan Dahua Road, Dongcheng, Beijing, 100730, China

    D. Wei

  3. The Sixth People’s Hospital of Weifang, No. 4116 Yongan Road, Weicheng, Weifang, Shandong Province, 261000, China

    B. Sun

  4. Beijing Key Laboratory of Learning and Cognition, Department of Psychology, Capital Normal University, No.105 Xisanhuan Beilu, Haidian, Beijing, 100048, China

    X. N. Wu

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  1. X. Wu
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Corresponding author

Correspondence to X. N. Wu.

Ethics declarations

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.

Conflicts of interest

None.

Funding

This questionnaire interview was supported by the National Natural Science Foundation of China (71401113).

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Wu, X., Wei, D., Sun, B. et al. Poor medication adherence to bisphosphonates and high self-perception of aging in elderly female patients with osteoporosis. Osteoporos Int 27, 3083–3090 (2016). https://doi.org/10.1007/s00198-016-3763-8

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  • DOI: https://doi.org/10.1007/s00198-016-3763-8

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