Skip to main content

Advertisement

SpringerLink
Log in

Errors in NOF meta-analyses of calcium and vitamin D supplements

  • Letter
  • Published:
Osteoporosis International Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Weaver CM, Alexander DD, Boushey CJ et al. (2015) Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation. Osteoporos Int 27(1):367--376

  2. Chapuy MC, Arlot ME, Duboeuf F et al (1992) Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 327:1637–42

    Article  CAS  PubMed  Google Scholar 

  3. Chapuy MC, Pamphile R, Paris E et al (2002) Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int 13:257–64

    Article  CAS  PubMed  Google Scholar 

  4. Grant AM, Avenell A, Campbell MK et al (2005) Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365:1621–8

    Article  CAS  PubMed  Google Scholar 

  5. Salovaara K, Tuppurainen M, Karkkainen M et al (2010) Effect of vitamin D(3) and calcium on fracture risk in 65- to 71-year-old women: a population-based 3-year randomized, controlled trial—the OSTPRE-FPS. J Bone Miner Res 25:1487–95

    Article  CAS  PubMed  Google Scholar 

  6. Bolland MJ, Grey A (2014) A case study of discordant overlapping meta-analyses: vitamin d supplements and fracture. PLoS One 9:e115934

    Article  PubMed  PubMed Central  Google Scholar 

  7. Avenell A, Grant AM, McGee M et al (2004) The effects of an open design on trial participant recruitment, compliance and retention—a randomized controlled trial comparison with a blinded, placebo-controlled design. Clin Trials 1:490–8

    Article  PubMed  Google Scholar 

  8. Bolton-Smith C, McMurdo ME, Paterson CR et al (2007) Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women. J Bone Miner Res 22:509–19

    Article  CAS  PubMed  Google Scholar 

  9. Avenell A, Gillespie WJ, Gillespie LD et al. (2009) Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. Cochrane Database Syst Rev CD000227

  10. Avenell A, Mak JC, O'Connell D (2014) Vitamin D and vitamin D analogues for preventing fractures in post-menopausal women and older men. Cochrane Database Syst Rev 4, CD000227

    PubMed  Google Scholar 

  11. Lopez-Torres Hidalgo J, Grupo A (2014) Effect of calcium and vitamin D in the reduction of falls in the elderly: a randomized trial versus placebo. Med Clin (Barc) 142:95–102

    Article  Google Scholar 

  12. Chapuy MC, Arlot ME, Delmas PD et al (1994) Effect of calcium and cholecalciferol treatment for three years on hip fractures in elderly women. BMJ 308:1081–2

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Sun X, Ioannidis JP, Agoritsas T et al (2014) How to use a subgroup analysis: users' guide to the medical literature. JAMA 311:405–11

    Article  CAS  PubMed  Google Scholar 

  14. Bolland MJ, Grey A, Gamble GD et al (2011) Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women's Health Initiative (WHI) limited-access data set. Am J Clin Nutr 94:1144–9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Robbins JA, Aragaki A, Crandall CJ et al (2014) Women's health initiative clinical trials: interaction of calcium and vitamin D with hormone therapy. Menopause 21:116–23

    Article  PubMed  PubMed Central  Google Scholar 

  16. Reid IR, Bolland MJ (2014) Calcium risk-benefit updated—new WHI analyses. Maturitas 77:1–3

    Article  PubMed  Google Scholar 

  17. http://commonhealth.wbur.org/2015/08/calcium-vitamin-d-commercial-influence Accessed November 30 2015

  18. Grey A, Bolland M (2015) Web of industry, advocacy, and academia in the management of osteoporosis. BMJ 351:h3170

    Article  PubMed  Google Scholar 

  19. Wang MTM, Gamble G, Bolland MJ et al (2014) Press releases issued by supplements industry organizations and non-industry organizations in response to publication of clinical research findings: a case–control study. PLoS One 9:e101533

    Article  PubMed  PubMed Central  Google Scholar 

  20. Bolland MJ, Grey A, Reid IR (2013) An inappropriate response? BMJ 346:f942

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medicine, University of Auckland, Private Bag 92 019, Auckland, 1142, New Zealand

    M. J. Bolland, A. Grey & I. R. Reid

  2. Health Services Research Unit, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland, UK

    A. Avenell

Authors
  1. M. J. Bolland
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Avenell
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. Grey
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. R. Reid
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. J. Bolland.

Ethics declarations

Conflicts of interest

All authors have co-authored meta-analyses of calcium and vitamin D supplements and fracture. MB has nothing else to declare. AG is a shareholder in Auckland Bone Density, a company that provides bone mineral density measurements. AA received funding from the Medical Research Council, Shire Pharmaceutical and Nycomed for funding of the RECORD trial. IRR research funding or consulting/speaking fees from Novartis, Merck, Amgen and Lilly

Funding

The study was funded by the Health Research Council (HRC) of New Zealand. MB is the recipient of a Sir Charles Hercus Health Research Fellowship. AA is funded by a Career Scientist award of the Chief Scientist Office of the Scottish Government Health Directorates. The Health Services Research Unit is funded by the Chief Scientist Office of the Scottish Government Health Directorates.

Additional information

The authors are independent of the Health Research Council (HRC). The HRC had no role in design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the manuscript; or decision to submit the manuscript for publication.

A response to these comments can be found at doi:10.1007/s00198-016-3525-7.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Bolland, M.J., Avenell, A., Grey, A. et al. Errors in NOF meta-analyses of calcium and vitamin D supplements. Osteoporos Int 27, 2637–2639 (2016). https://doi.org/10.1007/s00198-015-3466-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00198-015-3466-6

Keywords

Search

Navigation