Osteoporosis International

, Volume 27, Issue 4, pp 1507–1518

Efficacy of recreational football on bone health, body composition, and physical functioning in men with prostate cancer undergoing androgen deprivation therapy: 32-week follow-up of the FC prostate randomised controlled trial

  • J. Uth
  • T. Hornstrup
  • J. F. Christensen
  • K. B. Christensen
  • N. R. Jørgensen
  • J. F. Schmidt
  • K. Brasso
  • M. D. Jakobsen
  • E. Sundstrup
  • L. L. Andersen
  • M. Rørth
  • J. Midtgaard
  • P. Krustrup
  • E. W. Helge
Original Article

DOI: 10.1007/s00198-015-3399-0

Cite this article as:
Uth, J., Hornstrup, T., Christensen, J.F. et al. Osteoporos Int (2016) 27: 1507. doi:10.1007/s00198-015-3399-0

Abstract

Summary

Androgen deprivation therapy (ADT) for prostate cancer (PCa) impairs musculoskeletal health. We evaluated the efficacy of 32-week football training on bone mineral density (BMD) and physical functioning in men undergoing ADT for PCa. Football training improved the femoral shaft and total hip BMD and physical functioning parameters compared to control.

Introduction

ADT is a mainstay in PCa management. Side effects include decreased bone and muscle strength and increased fracture rates. The purpose of the present study was to evaluate the effects of 32 weeks of football training on BMD, bone turnover markers (BTMs), body composition, and physical functioning in men with PCa undergoing ADT.

Methods

Men receiving ADT >6 months (n = 57) were randomly allocated to a football training group (FTG) (n = 29) practising 2–3 times per week for 45–60 min or to a standard care control group (CON) (n = 28) for 32 weeks. Outcomes were total hip, femoral shaft, femoral neck and lumbar spine (L2-L4) BMD and systemic BTMs (procollagen type 1 amino-terminal propeptide, osteocalcin, C-terminal telopeptide of type 1 collagen). Additionally, physical functioning (postural balance, jump height, repeated chair rise, stair climbing) was evaluated.

Results

Thirty-two-week follow-up measures were obtained for FTG (n = 21) and for CON (n = 20), respectively. Analysis of mean changes from baseline to 32 weeks showed significant differences between FTG and CON in right (0.015 g/cm2) and left (0.017 g/cm2) total hip and in right (0.018 g/cm2) and left (0.024 g/cm2) femoral shaft BMD, jump height (1.7 cm) and stair climbing (−0.21 s) all in favour of FTG (p < 0.05). No other significant between-group differences were observed.

Conclusions

Compared to standard care, 32 weeks of football training improved BMD at clinically important femoral sites and parameters of physical functioning in men undergoing ADT for PCa.

Keywords

Androgen deprivation therapy Bone mineral density Bone turnover markers Exercise Physical activity Sport 

Funding information

Funder NameGrant NumberFunding Note
Preben og Anna Simonsens Fond
    The Beckett Foundation

      Copyright information

      © International Osteoporosis Foundation and National Osteoporosis Foundation 2015

      Authors and Affiliations

      • J. Uth
        • 1
      • T. Hornstrup
        • 2
      • J. F. Christensen
        • 3
      • K. B. Christensen
        • 4
      • N. R. Jørgensen
        • 5
        • 6
      • J. F. Schmidt
        • 2
      • K. Brasso
        • 7
      • M. D. Jakobsen
        • 8
      • E. Sundstrup
        • 8
      • L. L. Andersen
        • 8
        • 9
      • M. Rørth
        • 10
      • J. Midtgaard
        • 1
        • 11
      • P. Krustrup
        • 2
        • 12
      • E. W. Helge
        • 2
      1. 1.The University Hospitals Centre for Health Research (UCSF), RigshospitaletUniversity of CopenhagenCopenhagenDenmark
      2. 2.Department of Nutrition, Exercise and Sports, Copenhagen Centre for Team Sport and HealthUniversity of CopenhagenCopenhagenDenmark
      3. 3.Centre for Physical Activity Research, RigshospitaletUniversity of CopenhagenCopenhagenDenmark
      4. 4.Department of BiostatisticsUniversity of CopenhagenCopenhagenDenmark
      5. 5.Research Center for Ageing and Osteoporosis, Department of Clinical BiochemistryRigshospitaletGlostrupDenmark
      6. 6.Institute of Clinical ResearchUniversity of Southern DenmarkOdenseDenmark
      7. 7.Copenhagen Prostate Cancer Center, Department of Urology, RigshospitaletUniversity of CopenhagenCopenhagenDenmark
      8. 8.National Research Centre for the Working EnvironmentCopenhagenDenmark
      9. 9.Physical Activity and Human Performance group, SMI, Department of Health Science and TechnologyAalborg UniversityAalborgDenmark
      10. 10.Department of Oncology, RigshospitaletUniversity of CopenhagenCopenhagenDenmark
      11. 11.Department of Public HealthUniversity of CopenhagenCopenhagen KDenmark
      12. 12.Sport and Health Sciences, College of Life and Environmental SciencesUniversity of ExeterExeterUK

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