Abstract
Summary
Sarcopenia is the age-related reduction of skeletal muscle mass in older individuals. Respiratory muscle strength may be related to skeletal muscle mass and, thus, the present study attempted to estimate the risk of sarcopenia relative to decreased pulmonary function. The present findings demonstrated that low pulmonary function was associated with low muscle mass in community-dwelling older adults.
Introduction
Lean body mass is related to pulmonary function in patients with chronic obstructive pulmonary disease (COPD). However, the relationship between muscle mass and pulmonary function in healthy older adults has yet to be clarified. Thus, the present study investigated the association of pulmonary function with muscle mass in an older community-dwelling Korean population.
Methods
This study included 463 disease-free subjects over 65 years of age who underwent anthropometric measurements, laboratory tests, spirometry, and the estimation of appendicular skeletal muscle (ASM) mass in the 2008–2011 Korea National Health and Nutrition Examination Survey (KNHANES). Low muscle mass was defined as the value of ASM divided by height squared (ASM/height2) that was less than two standard deviations (SD) below the sex-specific mean of the young reference group.
Results
Forced expiratory volume in 1 s (FEV1[L]) and forced vital capacity (FVC[L]) were positively correlated with ASM/height2 in males (p < 0.001 and p = 0.001, respectively) but not in females (p = 0.360 and p = 0.779, respectively). A univariate logistic regression analysis revealed that males with low FEV1 or FVC were more likely to have low muscle mass (odds ratio [OR] = 3.11, 95 % confidence interval [CI] 1.62–5.99 for FEV1; OR = 1.99, 95 % CI 1.13–3.53 for FVC); similar results were found for females, but the significance was lower (OR = 11.37, 95 % CI 0.97–132.91 for FEV1; OR = 7.31, 95 % CI 1.25–42.74 for FVC). After adjusting for age, smoking, and moderate physical activity, a low FEV1 value was associated with low muscle mass in both males (OR = 2.90, 95 % CI 1.50–5.63) and females (OR = 9.15, 95 % CI 1.53–54.77).
Conclusions
Using nationally representative data from the 2008–2011 KNHANES, low pulmonary function was found to be associated with low muscle mass in community-dwelling older Korean adults.
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References
National Statistical Office of Korea (2012) Population Projections of Korea: 2010-2060 (based on the 2010 census). Korean National Statistical Office, Daejeon
Cruz-Jentoft AJ, Baeyens JP, Bauer JM et al (2010) Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing 39:412–423
Delmonico MJ, Harris TB, Lee JS, Visser M, Nevitt M, Kritchevsky SB, Tylavsky FA, Newman AB, Health, Aging and Body Composition Study (2007) Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc 55:769–774
Verschueren S, Gielen E, O'Neill TW et al (2013) Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men. Osteoporos Int 24:87–98
Cederholm T, Cruz-Jentoft AJ, Maggi S (2013) Sarcopenia and fragility fractures. Eur J Phys Rehabil Med 49:111–117
Goodpaster BH, Park SW, Harris TB, Kritchevsky SB, Nevitt M, Schwartz AV, Simonsick EM, Tylavsky FA, Visser M, Newman AB (2006) The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study. J Gerontol A: Biol Med Sci 61:1059–1064
Kim TN, Yang SJ, Yoo HJ et al (2009) Prevalence of sarcopenia and sarcopenic obesity in Korean adults: the Korean sarcopenic obesity study. Int J Obes 33:885–892
Sharma G, Goodwin J (2006) Effect of aging on respiratory system physiology and immunology. Clin Interv Aging 1:253–260
Lalley PM (2013) The aging respiratory system—pulmonary structure, function and neural control. Respir Physiol Neurobiol 187:199–210
Mannino DM, Buist AS, Petty TL, Enright PL, Redd SC (2003) Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study. Thorax 58:388–393
Kim HC, Mofarrahi M, Hussain SN (2008) Skeletal muscle dysfunction in patients with chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 3:637–658
Nishimura Y, Tsutsumi M, Nakata H, Tsunenari T, Maeda H, Yokoyama M (1995) Relationship between respiratory muscle strength and lean body mass in men with COPD. Chest 107:1232–1236
Santana H, Zoico E, Turcato E, Tosoni P, Bissoli L, Olivieri M, Bosello O, Zamboni M (2001) Relation between body composition, fat distribution, and lung function in elderly men. Am J Clin Nutr 73:827–831
Wannamethee SG, Shaper AG, Whincup PH (2005) Body fat distribution, body composition, and respiratory function in elderly men. Am J Clin Nutr 82:996–1003
Choi HS, Oh HJ, Choi H, Choi WH, Kim JG, Kim KM, Kim KJ, Rhee Y, Lim SK (2011) Vitamin D insufficiency in Korea—a greater threat to younger generation: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008. J Clin Endocrinol Metab 96:643–651
Ryan H, Trosclair A, Gfroerer J (2012) Adult current smoking: differences in definitions and prevalence estimates—NHIS and NSDUH, 2008. J Environ Public Health 2012, 918368
Cruz-Jentoft AJ, Landi F, Schneider SM et al (2014) Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age Ageing 43(6):748–759
Kjensli A, Ryg M, Falch JA, Armbrecht G, Diep LM, Eriksen EF, Ellingsen I (2010) Does body height reduction influence interpretation of lung function in COPD patients? Eur Respir J 36:540–548
Chung JH, Hwang HJ, Han CH, Son BS, Kim DH, Park MS (2014) Association between sarcopenia and metabolic syndrome in chronic obstructive pulmonary disease: the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011. COPD
Miller MR, Hankinson J, Brusasco V et al (2005) Standardisation of spirometry. Eur Respir J 26:319–338
Levy PS, Lemeshow S (1999) Sampling of populations: methods and applications, 3rd edn. Wiley-Interscience Publication, New York, pp 333–363
Lee ES, Forthofer RN (2006) Analyzing complex survey data, 2nd edn. SAGA Publications, London, pp 11–20
Wheeler DC, VanHorn JE, Paskett ED (2007) A comparison of design-based and model based analysis of sample survey in geography. Rollings School of Public Health, Emory University, Atlanta, pp 1–34
Lohr SL (2010) Sampling: design and analysis, 2nd edn. Brooks/Cole, Cengage Learning, Boston, pp 281–320
Bonita R, Beaglehole R, Kjellstro T (2006) Basic epidemiology, 2nd edn. World Health Organization, Geneva, pp 29–30
Jones RL, Nzekwu MM (2006) The effects of body mass index on lung volumes. Chest 130:827–833
Rossi A, Fantin F, Di Francesco V, Guariento S, Giuliano K, Fontana G, Micciolo R, Solerte SB, Bosello O, Zamboni M (2008) Body composition and pulmonary function in the elderly: a 7-year longitudinal study. Int J Obes 32:1423–1430
Sutherland TJ, Goulding A, Grant AM, Cowan JO, Williamson A, Williams SM, Skinner MA, Taylor DR (2008) The effect of adiposity measured by dual-energy X-ray absorptiometry on lung function. Eur Respir J 32:85–91
Annweiler C, Schott AM, Berrut G, Fantino B, Beauchet O (2009) Vitamin D-related changes in physical performance: a systematic review. J Nutr Health Aging 13:893–898
Bischoff-Ferrari HA, Dawson-Hughes B, Staehelin HB, Orav JE, Stuck AE, Theiler R, Wong JB, Egli A, Kiel DP, Henschkowski J (2009) Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomised controlled trials. BMJ 339:b3692
Kim MK, Baek KH, Song KH, Il Kang M, Park CY, Lee WY, Oh KW (2011) Vitamin D deficiency is associated with sarcopenia in older Koreans, regardless of obesity: the Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) 2009. J Clin Endocrinol Metab 96:3250–3256
Bischoff HA, Borchers M, Gudat F, Duermueller U, Theiler R, Stahelin HB, Dick W (2001) In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J 33:19–24
Marantes I, Achenbach SJ, Atkinson EJ, Khosla S, Melton LJ 3rd, Amin S (2011) Is vitamin D a determinant of muscle mass and strength? J Bone Miner Res Off J Am Soc Bone Miner Res 26:2860–2871
Hughes VA, Roubenoff R, Wood M, Frontera WR, Evans WJ, Fiatarone Singh MA (2004) Anthropometric assessment of 10-y changes in body composition in the elderly. Am J Clin Nutr 80:475–482
Brown AB, McCartney N, Sale DG (1990) Positive adaptations to weight-lifting training in the elderly. J Appl Physiol 69:1725–1733
Misic MM, Rosengren KS, Woods JA, Evans EM (2007) Muscle quality, aerobic fitness and fat mass predict lower-extremity physical function in community-dwelling older adults. Gerontology 53:260–266
Frontera WR, Meredith CN, O'Reilly KP, Knuttgen HG, Evans WJ (1988) Strength conditioning in older men: skeletal muscle hypertrophy and improved function. J Appl Physiol 64:1038–1044
Yarasheski KE, Zachwieja JJ, Bier DM (1993) Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women. Am J Physiol 265:E210–E214
Yeom HA, Jung D, Choi M (2011) Adherence to physical activity among older adults using a geographic information system: Korean National Health and Nutrition Examinations Survey IV. Asian Nurs Res (Korean Soc Nurs Sci) 5(2):118–127
Rom O, Kaisari S, Aizenbud D, Reznick AZ (2012) Sarcopenia and smoking: a possible cellular model of cigarette smoke effects on muscle protein breakdown. Ann N Y Acad Sci 1259:47–53
Chen LK, Liu LK, Woo J et al (2014) Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc 15:95–101
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No grants or fellowships supported the writing of this manuscript. The authors would like to thank Pusan National University Hospital Regional Center for Respiratory Diseases for their support in this work.
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Y. K. Jeon and M. J. Shin contributed equally to this work.
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Jeon, Y.K., Shin, M.J., Kim, M.H. et al. Low pulmonary function is related with a high risk of sarcopenia in community-dwelling older adults: the Korea National Health and Nutrition Examination Survey (KNHANES) 2008–2011. Osteoporos Int 26, 2423–2429 (2015). https://doi.org/10.1007/s00198-015-3152-8
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DOI: https://doi.org/10.1007/s00198-015-3152-8