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Alendronate-induced unmasking or deterioration of coeliac disease: a case series

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References

  1. Fleisch H (1993) Bisphosphonates: mechanisms of action and clinical use. In: Mundy GR, Martin TJ (eds) Physiology and pharmacology of bone, Handbook of experimental pharmacology. Springer-Verlag Berlin Heidelberg, New York, pp 377–418

    Chapter  Google Scholar 

  2. Kemppainen T, Kroger H, Janatuinen E, Arnala I, Kosma VM, Pikkarainen P, Julkunen R, Jurvelin J, Alhava E, Uusitupa M (1999) Osteoporosis in adult patients with celiac disease. Bone 24:249–255

    Article  CAS  PubMed  Google Scholar 

  3. Pistorius LR, Sweidan WH, Purdie DW, Steel SA, Howey S, Bennett JR, Sutton DR (1995) Coeliac disease and bone mineral density in adult female patients. Gut 37:639–642

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  4. Lindh E, Ljunghall S, Larsson K, Lavo B (1992) Screening for antibodies against gliadin in patients with osteoporosis. J Intern Med 231:403–406

    Article  CAS  PubMed  Google Scholar 

  5. Lebwohl B, Michaëlsson K, Green PHR, Ludvigsson JF (2014) Persistent mucosal damage and risk of fracture in celiac disease. J Clin Endocrinol Metab 99:609–616

    Article  CAS  PubMed  Google Scholar 

  6. Collin P, Kaukinen K, Maki M (1999) Clinical features of celiac disease today. Dig Dis 17:100–106

    Article  CAS  PubMed  Google Scholar 

  7. Bianchi ML, Bardella MT (2008) Bone in celiac disease. Osteoporos Int 19:1705–1716

    Article  PubMed  Google Scholar 

  8. Moss SF, Attia L, Scholes JV, Walters JRF, Holt PR (1996) Increased small intestinal apoptosis in coeliac disease. Gut 39:811–817

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  9. Giovanni C, Sanchez M, Straface E, Scazzocchio B, Silano M, Md V (2000) Induction of apoptosis in Caco-2 cells by wheat gliadin peptides. Toxicology 145:63–71

    Article  Google Scholar 

  10. Liberman UA, Weiss SR, Broll J, Minne HW, Quan H, Bell NH, Rodriguez-Portales J, Downs RW, Dequeker J, Favus M, Seeman E, Recker RR, Capizzi T, Santora AC, Lombardi A, Shah RV, Hirsch LJ, Karpf DB (1995) Effect of alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. N Engl J Med 333:1437–1443

    Article  CAS  PubMed  Google Scholar 

  11. Bauer DC, Black D, Ensrud K, Thompson D, Hochberg M, Nevitt M, Musliner T, Freedholm D (2000) Upper gastrointestinal tract safety profile of alendronate: the fracture intervention trial. Arch Intern Med 160:517–525

    Article  CAS  PubMed  Google Scholar 

  12. Kelly R, Taggart H (1997) Incidence of gastrointestinal side effects due to alendronate is high in clinical practice. Br Med J 315:1235

    Article  CAS  Google Scholar 

  13. de Groen PC, Lubbe DF, Hirsch LJ, Daifotis A, Stephenson W, Freedholm D, Pryor-Tillotson S, Seleznick MJ, Pinkas H, Wang KK (1996) Esophagitis associated with the use of alendronate. N Engl J Med 335:1016–1021

    Article  PubMed  Google Scholar 

  14. Parfitt JR, Driman DK (2007) Pathological effects of drugs on the gastrointestinal tract: a review. Hum Pathol 38:527–536

    Article  CAS  PubMed  Google Scholar 

  15. Peng YL, Hu HY, Luo JC, Hou MC, Lin HC, Lee FY (2014) Alendronate, a bisphosphonate, increased upper and lower gastrointestinal bleeding: risk factor analysis from a nationwide population-based study. Osteoporos Int 25:1617–1623

    Article  CAS  PubMed  Google Scholar 

  16. Mok JO, Jung CH, Kim CH, Ryu CB, Kim YJ, Kim SJ, Park HK, Suh KI, Yoo MH, Byun D-W (2013) Endoscopic comparison of alendronate alone and the enteric-coated alendronate with calcitriol combination in postmenopausal Korean females. Korean J Intern Med 28:694–700

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Twiss IM, Pas O, Ramp-Koopmanschap W, Den Hartigh J, Vermeij P (1999) The effects of nitrogen-containing bisphosphonates on human epithelial (Caco-2) cells, an in vitro model for intestinal epithelium. J Bone Miner Res 14:784–791

    Article  CAS  PubMed  Google Scholar 

  18. Twiss IM, van den Berk AHM, de Kam ML, Bosch JJ, Cohen AF, Vermeij P, Burggraaf J (2006) A comparison of the gastrointestinal effects of the nitrogen-containing bisphosphonates pamidronate, alendronate, and olpadronate in humans. J Clin Pharmacol 46:483–487

    Article  CAS  PubMed  Google Scholar 

  19. eHealthMe. http://www.ehealthme.com/ds/fosamax/celiac+disease+−+sprue. Accessed 5 Oct 2014

  20. Meek SE, Nix K (2007) Hypocalcemia after alendronate therapy in a patient with celiac disease. Endocr Pract 13:403–407

    Article  PubMed  Google Scholar 

  21. Lewis NR, Scott BB, for the British Society of Gastroenterology (2007) Guidelines for osteoporosis in inflammatory bowel disease and coeliac disease. http://www.bsg.org.uk/clinical-guidelines/ibd/guidelines-for-osteoporosis-in-inflammatory-bowel-disease-and-coeliac-disease.html. Accessed 23 Oct 2014

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Correspondence to B. G. A. Stuckey.

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Stuckey, B.G.A., Sallie, R. Alendronate-induced unmasking or deterioration of coeliac disease: a case series. Osteoporos Int 26, 411–414 (2015). https://doi.org/10.1007/s00198-014-2942-8

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  • DOI: https://doi.org/10.1007/s00198-014-2942-8

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