This is a preview of subscription content, access via your institution.
References
Walsh JS, Newman C, Eastell R (2012) Heart drugs that affect bone. Trends Endocrinol Metab 23:163–168
Misra D, Zhang Y, Peloquin C, Choi HK, Kiel DP, Neogi T (2014) Incident long-term warfarin use and risk of osteoporotic fractures: propensity-score matched cohort of elders with new onset atrial fibrillation. Osteoporos Int 25:1677–1684. doi:10.1007/s00198-014-2662-0
Sugiyama T, Takaki T, Sakanaka K, Sadamura H, Mori K, Kato Y, Taguchi T, Saito T (2007) Warfarin-induced impairment of cortical bone material quality and compensatory adaptation of cortical bone structure to mechanical stimuli. J Endocrinol 194:213–222
Kavukcuoglu NB, Patterson-Buckendahl P, Mann AB (2009) Effect of osteocalcin deficiency on the nanomechanics and chemistry of mouse bones. J Mech Behav Biomed Mater 2:348–354
Rey-Sanchez P, Lavado-Garcia JM, Canal-Macias ML, Rodriguez-Dominguez MT, Bote-Mohedano JL, Pedrera-Zamorano JD (2011) Ultrasound bone mass in patients undergoing chronic therapy with oral anticoagulants. J Bone Miner Metab 29:546–551
Sugiyama T, Kawai S (2001) Carboxylation of osteocalcin may be related to bone quality: a possible mechanism of bone fracture prevention by vitamin K. J Bone Miner Metab 19:146–149
Sugiyama T (2013) Vitamin D and calcium supplementation to prevent fractures in adults. Ann Intern Med 159:856
Sugiyama T, Kawai S (2004) Quantitative ultrasound, skeletal quality, and fracture risk. Lancet 363:1076–1077
Shanbhogue VV, Hansen S, Folkestad L, Brixen K, Beck-Nielsen SS (2014) Bone geometry, volumetric density, microarchitecture and estimated bone strength assessed by HR-pQCT in adult patients with hypophosphatemic rickets. J Bone Miner Res. doi:10.1002/jbmr.2310
Sugiyama T, Taguchi T, Kawai S (2002) Adaptation of bone to mechanical loads. Lancet 359:1160
Sugiyama T, Yamaguchi A, Kawai S (2002) Effects of skeletal loading on bone mass and compensation mechanism in bone: a new insight into the “mechanostat” theory. J Bone Miner Metab 20:196–200
Jamal SA, Browner WS, Bauer DC, Cummings SR (1998) Warfarin use and risk for osteoporosis in elderly women. Study of Osteoporotic Fractures Research Group. Ann Intern Med 128:829–832
Caraballo PJ, Heit JA, Atkinson EJ, Silverstein MD, O’Fallon WM, Castro MR, Melton LJ 3rd (1999) Long-term use of oral anticoagulants and the risk of fracture. Arch Intern Med 159:1750–1756
Mamdani M, Upshur RE, Anderson G, Bartle BR, Laupacis A (2003) Warfarin therapy and risk of hip fracture among elderly patients. Pharmacotherapy 23:1–4
Pilon D, Castilloux AM, Dorais M, LeLorier J (2004) Oral anticoagulants and the risk of osteoporotic fractures among elderly. Pharmacoepidemiol Drug Saf 13:289–294
Gage BF, Birman-Deych E, Radford MJ, Nilasena DS, Binder EF (2006) Risk of osteoporotic fracture in elderly patients taking warfarin: results from the National Registry of Atrial Fibrillation 2. Arch Intern Med 166:241–246
Rejnmark L, Vestergaard P, Mosekilde L (2007) Fracture risk in users of oral anticoagulants: a nationwide case-control study. Int J Cardiol 118:338–344
Woo C, Chang LL, Ewing SK, Bauer DC, Osteoporotic Fractures in Men Study Group (2008) Single-point assessment of warfarin use and risk of osteoporosis in elderly men. J Am Geriatr Soc 56:1171–1176
Sato Y, Honda Y, Jun I (2010) Long-term oral anticoagulation therapy and the risk of hip fracture in patients with previous hemispheric infarction and nonrheumatic atrial fibrillation. Cerebrovasc Dis 29:73–78
Fusaro M, Tripepi G, Noale M, Plebani M, Zaninotto M, Piccoli A, Naso A, Miozzo D, Giannini S, Avolio M, Foschi A, Rizzo MA, Gallieni M, The Vertebral Fractures Vascular Calcifications Study Group (2014) Prevalence of vertebral fractures, vascular calcifications, and mortality in warfarin treated hemodialysis patients. Curr Vasc Pharmacol. doi:10.2174/15701611113119990146
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Sugiyama, T., Kugimiya, F., Kono, S. et al. Warfarin use and fracture risk: an evidence-based mechanistic insight. Osteoporos Int 26, 1231–1232 (2015). https://doi.org/10.1007/s00198-014-2912-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00198-014-2912-1
Keywords
- Warfarin
- Fracture Risk
- Osteocalcin
- Hypophosphatemic Rickets
- Onset Atrial Fibrillation