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Celiac disease and risk of fracture in adults—a review

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Abstract

Patients with celiac disease (CD) have low bone mineral density. Evidence of increased fracture risk in these patients is conflicting, and the indication for bone mineral density screening of all adult CD patients is debated. Our aim was to review current published data on fractures in CD. Cross-sectional cohort studies and one case study were identified by searching Medline and Embase. Although the identified studies are heterogeneous and difficult to compare, the overall findings indicate a positive association between CD and risk of fracture. Adult patients with CD should be considered for bone densitometry in order to estimate fracture risk.

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Acknowledgments

We thank Sigrun M. Hjelle and Karl Ove Hufthammer for the editorial and statistical assistance.

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Authors and Affiliations

  1. Department of Rheumatology, Division of Medicine, District General Hospital of Førde, PO Box 1000, 6807, Førde, Norway

    A. M. Hjelle & P. Mielnik

  2. Department of Rheumatology, Haukeland University Hospital, Bergen, Norway

    E. Apalset

  3. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway

    E. Apalset & G. S. Tell

  4. Section of Specialized Endocrinology, Oslo University Hospital, Oslo, Norway

    J. Bollerslev

  5. Department of Gastroenterology, Oslo University Hospital Rikshospitalet, Oslo, Norway

    K. E. A. Lundin

  6. Center for Immune Regulation, University of Oslo, Oslo, Norway

    K. E. A. Lundin

  7. Faculty of Medicine, University of Oslo, Oslo, Norway

    J. Bollerslev & K. E. A. Lundin

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  1. A. M. Hjelle
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  2. E. Apalset
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  3. P. Mielnik
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  5. K. E. A. Lundin
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  6. G. S. Tell
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Correspondence to A. M. Hjelle.

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Hjelle, A.M., Apalset, E., Mielnik, P. et al. Celiac disease and risk of fracture in adults—a review. Osteoporos Int 25, 1667–1676 (2014). https://doi.org/10.1007/s00198-014-2683-8

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  • DOI: https://doi.org/10.1007/s00198-014-2683-8

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