A higher alkaline dietary load is associated with greater indexes of skeletal muscle mass in women
Conservation of muscle mass is important for fall and fracture prevention but further understanding of the causes of age-related muscle loss is required. This study found a more alkaline diet was positively associated with muscle mass in women suggesting a role for dietary acid–base load in muscle loss.
Conservation of skeletal muscle is important for preventing falls and fractures but age-related loss of muscle mass occurs even in healthy individuals. However, the mild metabolic acidosis associated with an acidogenic dietary acid–base load could influence loss of muscle mass.
We investigated the association between fat-free mass (FFM), percentage FFM (FFM%) and fat-free mass index (FFMI, weight/height2), measured using dual-energy X-ray absorptiometry in 2,689 women aged 18–79 years from the TwinsUK Study, and dietary acid–base load. Body composition was calculated according to quartile of potential renal acid load and adjusted for age, physical activity, misreporting and smoking habit (FFM, FFMI also for fat mass) and additionally with percentage protein.
Fat-free mass was positively associated with a more alkalinogenic dietary load (comparing quartile 1 vs 4: FFM 0.79 kg P < 0.001, FFM% 1.06 % <0.001, FFMI 0.24 kg/m2P = 0.002), and with the ratio of fruits and vegetables to potential acidogenic foods.
We observed a small but significant positive association between a more alkaline diet and muscle mass indexes in healthy women that was independent of age, physical activity and protein intake equating to a scale of effect between a fifth and one half of the observed relationship with 10 years of age. Although protein is important for maintenance of muscle mass, eating fruits and vegetables that supply adequate amounts of potassium and magnesium are also relevant. The results suggest a potential role for diet in the prevention of muscle loss.
KeywordsDiet acid–base Load Fat-free mass Muscle Potential renal acid load (PRAL) Sarcopenia
- 3.Morley JE, Argiles JM, Evans WJ, Bhasin S, Cella D, Deutz NE, Doehner W, Fearon KC, Ferrucci L, Hellerstein MK, Kalantar-Zadeh K, Lochs H, MacDonald N, Mulligan K, Muscaritoli M, Ponikowski P, Posthauer ME, Rossi Fanelli F, Schambelan M, Schols AM, Schuster MW, Anker SD (2010) Nutritional recommendations for the management of sarcopenia. J Am Med Dir Assoc 11(6):391–396. doi:10.1016/j.jamda.2010.04.014 PubMedCrossRefGoogle Scholar
- 5.Foundation IO (2010) Facts and statistics about osteoporosis and its impact. http://www.iofbonehealth.org/facts-and-statistics.html. Accessed 14/01/11 2010
- 6.Bogl LH, Latvala A, Kaprio J, Sovijarvi O, Rissanen A, Pietilainen KH An investigation into the relationship between soft tissue body composition and bone mineral density in a young adult twin sample. J Bone Miner Res 26 (1):79–87. doi:10.1002/jbmr.192
- 10.Rolland Y, Lauwers-Cances V, Cristini C, Abellan van Kan G, Janssen I, Morley JE, Vellas B (2009) Difficulties with physical function associated with obesity, sarcopenia, and sarcopenic-obesity in community-dwelling elderly women: the EPIDOS (EPIDemiologie de l'OSteoporose) Study. Am J Clin Nutr 89(6):1895–1900. doi:10.3945/ajcn.2008.26950 PubMedCrossRefGoogle Scholar
- 12.Workeneh BT, Rondon-Berrios H, Zhang L, Hu Z, Ayehu G, Ferrando A, Kopple JD, Wang H, Storer T, Fournier M, Lee SW, Du J, Mitch WE (2006) Development of a diagnostic method for detecting increased muscle protein degradation in patients with catabolic conditions. J Am Soc Nephrol 17(11):3233–3239. doi:10.1681/ASN.2006020131 PubMedCrossRefGoogle Scholar
- 17.Welch AA, Mulligan A, Bingham SA, Khaw KT (2008) Urine pH is an indicator of dietary acid–base load, fruit and vegetables and meat intakes: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk population study. Br J Nutr 99(6):1335–1343. doi:10.1017/S0007114507862350 PubMedCrossRefGoogle Scholar
- 21.Macdonald HM, New SA, Fraser WD, Campbell MK, Reid DM (2005) Low dietary potassium intakes and high dietary estimates of net endogenous acid production are associated with low bone mineral density in premenopausal women and increased markers of bone resorption in postmenopausal women. Am J Clin Nutr 81(4):923–933PubMedGoogle Scholar
- 24.Ceglia L, Harris SS, Abrams SA, Rasmussen HM, Dallal GE, Dawson-Hughes B (2009) Potassium bicarbonate attenuates the urinary nitrogen excretion that accompanies an increase in dietary protein and may promote calcium absorption. J Clin Endocrinol Metab 94(2):645–653. doi:10.1210/jc.2008-1796 PubMedCrossRefGoogle Scholar
- 28.Cassidy A, Skidmore P, Rimm EB, Welch A, Fairweather-Tait S, Skinner J, Burling K, Richards JB, Spector TD, MacGregor AJ (2009) Plasma adiponectin concentrations are associated with body composition and plant-based dietary factors in female twins. J Nutr 139(2):353–358. doi:10.3945/jn.108.098681 PubMedGoogle Scholar
- 30.Teucher B, Skinner J, Skidmore PM, Cassidy A, Fairweather-Tait SJ, Hooper L, Roe MA, Foxall R, Oyston SL, Cherkas LF, Perks UC, Spector TD, MacGregor AJ (2007) Dietary patterns and heritability of food choice in a UK female twin cohort. Twin Res Hum Genet 10(5):734–748. doi:10.1375/twin.10.5.734 PubMedCrossRefGoogle Scholar
- 34.Agency FS (2002) McCance and Widdowson’s the composition of foods sixth summary edition. Royal Society of Chemistry, CambridgeGoogle Scholar
- 35.Otten JJ, Hellwig JP, Meyers LD (2006) DRI, dietary reference intakes: the essential guide to nutrient requirements. National Academies Press, Washington, D.CGoogle Scholar
- 40.Petersen AM, Magkos F, Atherton P, Selby A, Smith K, Rennie MJ, Pedersen BK, Mittendorfer B (2007) Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle. Am J Physiol Endocrinol Metab 293(3):E843–848. doi:10.1152/ajpendo.00301.2007 PubMedCrossRefGoogle Scholar