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Racial differences in cortical bone and their relationship to biochemical variables in Black and White children in the early stages of puberty

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Abstract

Summary

Osteoporotic fracture rates differ according to race with Blacks having up to half the rate of Whites. The current study demonstrates that racial divergence in cortical bone properties develops in early childhood despite lower serum 25-hydroxyvitamin D in Blacks.

Introduction

Racial differences in bone structure likely have roots in childhood as bone size develops predominantly during growth. This study aimed to compare cortical bone health within the tibial diaphysis of Black and White children in the early stages of puberty and explore the contributions of biochemical variables in explaining racial variation in cortical bone properties.

Methods

A cross-sectional study was performed comparing peripheral quantitative computed tomography-derived cortical bone measures of the tibial diaphysis and biochemical variables in 314 participants (n = 155 males; n = 164 Blacks) in the early stages of puberty.

Results

Blacks had greater cortical volumetric bone mineral density, mass, and size compared to Whites (all p < 0.01), contributing to Blacks having 17.0 % greater tibial strength (polar strength–strain index (SSIP)) (p < 0.001). Turnover markers indicated that Blacks had higher bone formation (osteocalcin (OC) and bone-specific alkaline phosphatase) and lower bone resorption (N-terminal telopeptide) than Whites (all p < 0.01). Blacks also had lower 25-hydroxyvitamin D (25(OH)D) and higher 1,25-dihydroxyvitamin D (1,25(OH)2D) and parathyroid hormone (PTH) (all p < 0.05). There were no correlations between tibial bone properties and 25(OH)D and PTH in Whites (all p ≥ 0.10); however, SSIP was negatively and positively correlated with 25(OH)D and PTH in Blacks, respectively (all p ≤ 0.02). Variation in bone cross-sectional area and SSIP attributable to race was partially explained by tibial length, 25(OH)D/PTH, and OC.

Conclusions

Divergence in tibial cortical bone properties between Blacks and Whites is established by the early stages of puberty with the enhanced cortical bone properties in Black children possibly being explained by higher PTH and OC.

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References

  1. Barrett-Connor E, Siris ES, Wehren LE, Miller PD, Abbott TA, Berger ML, Santora AC, Sherwood LM (2005) Osteoporosis and fracture risk in women of different ethnic groups. J Bone Miner Res 20:185–194

    Article  PubMed  Google Scholar 

  2. Cauley JA, Wu L, Wampler NS, Barnhart JM, Allison M, Chen Z, Jackson R, Robbins J (2007) Clinical risk factors for fractures in multi-ethnic women: the Women’s Health Initiative. J Bone Miner Res 22:1816–1826

    Article  PubMed  Google Scholar 

  3. Ettinger B, Sidney S, Cummings SR, Libanati C, Bikle DD, Tekawa IS, Tolan K, Steiger P (1997) Racial differences in bone density between young adult Black and White subjects persist after adjustment for anthropometric, lifestyle, and biochemical differences. J Clin Endocrinol Metab 82:429–434

    Article  PubMed  CAS  Google Scholar 

  4. Luckey MM, Meier DE, Mandeli JP, DaCosta MC, Hubbard ML, Goldsmith SJ (1989) Radial and vertebral bone density in White and Black women: evidence for racial differences in premenopausal bone homeostasis. J Clin Endocrinol Metab 69:762–770

    Article  PubMed  CAS  Google Scholar 

  5. Cauley JA, Lui LY, Stone KL, Hillier TA, Zmuda JM, Hochberg M, Beck TJ, Ensrud KE (2005) Longitudinal study of changes in hip bone mineral density in Caucasian and African-American women. J Am Geriatr Soc 53:183–189

    Article  PubMed  Google Scholar 

  6. Tracy JK, Meyer WA, Flores RH, Wilson PD, Hochberg MC (2005) Racial differences in rate of decline in bone mass in older men: the Baltimore men’s osteoporosis study. J Bone Miner Res 20:1228–1234

    Article  PubMed  Google Scholar 

  7. Black DM, Bouxsein ML, Marshall LM, Cummings SR, Lang TF, Cauley JA, Ensrud KE, Nielson CM, Orwoll ES (2008) Proximal femoral structure and the prediction of hip fracture in men: a large prospective study using QCT. J Bone Miner Res 23:1326–1333

    Article  PubMed  Google Scholar 

  8. Garn SM, Nagy JM, Sandusky ST (1972) Differential sexual dimorphism in bone diameters of subjects of European and African ancestry. Am J Phys Anthropol 37:127–129

    Article  PubMed  CAS  Google Scholar 

  9. Gilsanz V, Skaggs DL, Kovanlikaya A, Sayre J, Loro ML, Kaufman F, Korenman SG (1998) Differential effect of race on the axial and appendicular skeletons of children. J Clin Endocrinol Metab 83:1420–1427

    Article  PubMed  CAS  Google Scholar 

  10. Leonard MB, Elmi A, Mostoufi-Moab S, Shults J, Burnham JM, Thayu M, Kibe L, Wetzsteon RJ, Zemel BS (2010) Effects of sex, race, and puberty on cortical bone and the functional muscle bone unit in children, adolescents, and young adults. J Clin Endocrinol Metab 95:1681–1689

    Article  PubMed  CAS  Google Scholar 

  11. Micklesfield LK, Norris SA, Pettifor JM (2011) Determinants of bone size and strength in 13-year-old South African children: the influence of ethnicity, sex and pubertal maturation. Bone 48:777–785

    Article  PubMed  Google Scholar 

  12. Pollock NK, Laing EM, Taylor RG, Baile CA, Hamrick MW, Hall DB, Lewis RD (2011) Comparisons of trabecular and cortical bone in late adolescent Black and White females. J Bone Miner Metab 29:44–53

    Article  PubMed  Google Scholar 

  13. Wetzsteon RJ, Hughes JM, Kaufman BC, Vazquez G, Stoffregen TA, Stovitz SD, Petit MA (2009) Ethnic differences in bone geometry and strength are apparent in childhood. Bone 44:970–975

    Article  PubMed  CAS  Google Scholar 

  14. Wetzsteon RJ, Zemel BS, Shults J, Howard KM, Kibe LW, Leonard MB (2011) Mechanical loads and cortical bone geometry in healthy children and young adults. Bone 48:1103–1108

    Article  PubMed  Google Scholar 

  15. Harkness L, Cromer B (2005) Low levels of 25-hydroxyvitamin D are associated with elevated parathyroid hormone in healthy adolescent females. Osteoporos Int 16:109–113

    Article  PubMed  CAS  Google Scholar 

  16. Hui SL, Dimeglio LA, Longcope C, Peacock M, McClintock R, Perkins AJ, Johnston CC Jr (2003) Difference in bone mass between Black and White American children: attributable to body build, sex hormone levels, or bone turnover? J Clin Endocrinol Metab 88:642–649

    Article  PubMed  CAS  Google Scholar 

  17. Stein EM, Laing EM, Hall DB, Hausman DB, Kimlin MG, Johnson MA, Modlesky CM, Wilson AR, Lewis RD (2006) Serum 25-hydroxyvitamin D concentrations in girls aged 4–8 y living in the southeastern United States. Am J Clin Nutr 83:75–81

    PubMed  CAS  Google Scholar 

  18. Weaver CM, McCabe LD, McCabe GP, Braun M, Martin BR, Dimeglio LA, Peacock M (2008) Vitamin D status and calcium metabolism in adolescent Black and White girls on a range of controlled calcium intakes. J Clin Endocrinol Metab 93:3907–3914

    Article  PubMed  CAS  Google Scholar 

  19. Weng FL, Shults J, Leonard MB, Stallings VA, Zemel BS (2007) Risk factors for low serum 25-hydroxyvitamin D concentrations in otherwise healthy children and adolescents. Am J Clin Nutr 86:150–158

    PubMed  CAS  Google Scholar 

  20. Willis CM, Laing EM, Hall DB, Hausman DB, Lewis RD (2007) A prospective analysis of plasma 25-hydroxyvitamin D concentrations in White and Black prepubertal females in the southeastern United States. Am J Clin Nutr 85:124–130

    PubMed  CAS  Google Scholar 

  21. Bryant RJ, Wastney ME, Martin BR, Wood O, McCabe GP, Morshidi M, Smith DL, Peacock M, Weaver CM (2003) Racial differences in bone turnover and calcium metabolism in adolescent females. J Clin Endocrinol Metab 88:1043–1047

    Article  PubMed  CAS  Google Scholar 

  22. Braun M, Palacios C, Wigertz K, Jackman LA, Bryant RJ, McCabe LD, Martin BR, McCabe GP, Peacock M, Weaver CM (2007) Racial differences in skeletal calcium retention in adolescent girls with varied controlled calcium intakes. Am J Clin Nutr 85:1657–1663

    PubMed  CAS  Google Scholar 

  23. Pratt JH, Manatunga AK, Peacock M (1996) A comparison of the urinary excretion of bone resorptive products in White and Black children. J Lab Clin Med 127:67–70

    Article  PubMed  CAS  Google Scholar 

  24. Tanner J (1962) Growth at adolescence. Blackwell, Oxford

    Google Scholar 

  25. Centers for Disease Control and Prevention. BMI Percentile Calculator for Child and Teen. Centers for Disease Control and Prevention, Atlanta. http://apps.nccd.cdc.gov/dnpabmi

  26. Taylor RW, Goulding A (1998) Validation of a short food frequency questionnaire to assess calcium intake in children aged 3 to 6 years. Eur J Clin Nutr 52:464–465

    Article  PubMed  CAS  Google Scholar 

  27. Pate R, Ross R, Dowda M, Trost S, Sirard J (2003) Validation of a 3-day physical activity recall instrument in female youth. Pediatr Exerc Sci 15:257–265

    Google Scholar 

  28. Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, O’Brien WL, Bassett DR Jr, Schmitz KH, Emplaincourt PO, Jacobs DR Jr, Leon AS (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32:S498–S504

    Article  PubMed  CAS  Google Scholar 

  29. Wilhelm G, Felsenberg D, Bogusch G, Willnecker J, Thaten J, Gummert P (2001) Biomechanical examinations for validation of the bone strength strain index SSI, calculated by peripheral quantitative computed tomography. In: Lyritis G (ed) Musculoskeletal Interactions. Hylonome, Athens, pp 105–110

    Google Scholar 

  30. Macdonald H, Kontulainen S, Petit M, Janssen P, McKay H (2006) Bone strength and its determinants in pre- and early pubertal boys and girls. Bone 39:598–608

    Article  PubMed  Google Scholar 

  31. Rauch F, Schoenau E (2008) Peripheral quantitative computed tomography of the proximal radius in young subjects: new reference data and interpretation of results. J Musculoskelet Neuronal Interact 8:217–226

    PubMed  CAS  Google Scholar 

  32. Swinford RR, Warden SJ (2010) Factors affecting short-term precision of musculoskeletal measures using peripheral quantitative computed tomography (pQCT). Osteoporos Int 21:1863–1870

    Article  PubMed  CAS  Google Scholar 

  33. Marshall LM, Zmuda JM, Chan BK, Barrett-Connor E, Cauley JA, Ensrud KE, Lang TF, Orwoll ES (2008) Race and ethnic variation in proximal femur structure and BMD among older men. J Bone Miner Res 23:121–130

    Article  PubMed  Google Scholar 

  34. Peacock M, Buckwalter KA, Persohn S, Hangartner TN, Econs MJ, Hui S (2009) Race and sex differences in bone mineral density and geometry at the femur. Bone 45:218–225

    Article  PubMed  CAS  Google Scholar 

  35. Bachrach LK, Hastie T, Wang MC, Narasimhan B, Marcus R (1999) Bone mineral acquisition in healthy Asian, Hispanic, Black, and Caucasian youth: a longitudinal study. J Clin Endocrinol Metab 84:4702–4712

    Article  PubMed  CAS  Google Scholar 

  36. Hui SL, Perkins AJ, Harezlak J, Peacock M, McClintock CL, Johnston CC Jr (2010) Velocities of bone mineral accrual in Black and White American children. J Bone Miner Res 25:1527–1535

    Article  PubMed  Google Scholar 

  37. Nelson DA, Simpson PM, Johnson CC, Barondess DA, Kleerekoper M (1997) The accumulation of whole body skeletal mass in third- and fourth-grade children: effects of age, gender, ethnicity, and body composition. Bone 20:73–78

    Article  PubMed  CAS  Google Scholar 

  38. Rizzoli R, Bianchi ML, Garabedian M, McKay HA, Moreno LA (2010) Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderly. Bone 46:294–305

    Article  PubMed  Google Scholar 

  39. Ruff CB (1984) Allometry between length and cross-sectional dimensions of the femur and tibia in Homo sapiens sapiens. Am J Phys Anthropol 65:347–358

    Article  PubMed  CAS  Google Scholar 

  40. Weaver CM, Peacock M, Martin BR, Plawecki KL, McCabe GP (1996) Calcium retention estimated from indicators of skeletal status in adolescent girls and young women. Am J Clin Nutr 64:67–70

    PubMed  CAS  Google Scholar 

  41. Breen ME, Laing EM, Hall DB, Hausman DB, Taylor RG, Isales CM, Ding KH, Pollock NK, Hamrick MW, Baile CA, Lewis RD (2011) 25-Hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth. J Clin Endocrinol Metab 96:E89–E98

    Article  PubMed  CAS  Google Scholar 

  42. Tylavsky FA, Ryder KM, Li R, Park V, Womack C, Norwood J, Carbone LD, Cheng S (2007) Preliminary findings: 25(OH)D levels and PTH are indicators of rapid bone accrual in pubertal children. J Am Coll Nutr 26:462–470

    PubMed  CAS  Google Scholar 

  43. Hock JM (2001) Anabolic actions of PTH in the skeletons of animals. J Musculoskelet Neuronal Interact 2:33–47

    PubMed  CAS  Google Scholar 

  44. Hodsman AB, Bauer DC, Dempster D, Dian L, Hanley DA, Harris ST, Kendler D, McClung MR, Miller PD, Olszynski WP, Orwoll E, Yuen CK (2005) Parathyroid hormone and teriparatide for the treatment of osteoporosis: a review of the evidence and suggested guidelines for its use. Endocr Rev 26:688–703

    Article  PubMed  CAS  Google Scholar 

  45. Hill KM, Laing EM, Hausman DB, Acton A, Martin BR, McCabe GP, Weaver CM, Lewis RD, Peacock M (2012) Bone turnover is not influenced by serum 25-hydroxyvitamin D in pubertal healthy Black and White children. Bone 51(4):795–799

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

This contribution was made possible by support from the National Institutes of Health (R01-HD057126).

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Authors and Affiliations

  1. Center for Translational Musculoskeletal Research and Department of Physical Therapy, School of Health and Rehabilitation Sciences, Indiana University, 1140 W. Michigan St., CF-326, Indianapolis, IN, 46202, USA

    S. J. Warden

  2. Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    K. M. Hill & M. Peacock

  3. Department of Foods and Nutrition, College of Family and Consumer Sciences, University of Georgia, Athens, GA, USA

    A. J. Ferira, E. M. Laing, D. B. Hausman & R. D. Lewis

  4. Department of Foods and Nutrition, College of Consumer and Family Sciences, Purdue University, West Lafayette, IN, USA

    B. R. Martin & C. M. Weaver

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  1. S. J. Warden
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Correspondence to S. J. Warden.

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Warden, S.J., Hill, K.M., Ferira, A.J. et al. Racial differences in cortical bone and their relationship to biochemical variables in Black and White children in the early stages of puberty. Osteoporos Int 24, 1869–1879 (2013). https://doi.org/10.1007/s00198-012-2174-8

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  • DOI: https://doi.org/10.1007/s00198-012-2174-8

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