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Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women

Osteoporosis International volume 24, pages 1513–1518 (2013)Cite this article

Abstract

Summary

In animals, defective brown adipogenesis leads to bone loss. Whether brown adipose tissue (BAT) mass relates to bone mineral density (BMD) in humans is unclear. We determined the relationship between BAT mass and BMD by cold-stimulated positron-emission tomography (PET) and dual-energy X-ray absorptiometry (DXA) in healthy volunteers. Higher BAT mass was associated with higher BMD in healthy women, but not in men, independent of age and body composition.

Introduction

Contrary to the traditional belief that BAT is present only in infants, recent studies revealed significant depots of BAT present in adult humans. In animals, defective brown adipogenesis leads to bone loss. While white adipose tissue mass is a known determinant of BMD in humans, the relationship between BAT and BMD in humans is unclear. We thus examined the relationship between BAT and BMD in healthy adults.

Methods

BAT volume (ml) and activity (standard uptake value) were determined by 18F-fluorodeoxyglucose PET after overnight mild cold exposure at 19 °C, and BMD was determined by DXA.

Results

Among 24 healthy adults (age 28 ± 1 years, F = 10), BAT volumes were 82.4 ± 99.5 ml in women and 49.7 ± 54.5 ml in men. Women manifested significantly higher BAT activity, by 9.4 ± 8.1 % (p = 0.03), than men. BAT volume correlated positively with total and spine BMD (r 2 = 0.40 and 0.49, respectively, p < 0.02) in women and remained a significant predictor after adjustment for age, fat, and lean body mass (p < 0.05). Total and spine BMD were higher in women who harbored visually detectable BAT on PET images than those without by 11 ± 2 % (p = 0.02) and 22 ± 2 % (p < 0.01), respectively. No associations were observed between BAT parameters and BMD in men.

Conclusions

This study demonstrated higher BMD among healthy women with more abundant BAT, independent of age and other body compositional parameters. This was not observed in men. The data suggest that brown adipogenesis may be physiologically related to modulation of bone density.

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Acknowledgments

Paul Lee was supported by the Australian National Health Medical Research Council Early Career Fellowship, the Diabetes Australia Fellowship, and the Bushell Travelling Fellowship. This study was supported by the Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases: programs Z01-DK047057-02 and Z01-DK071044.

Conflicts of interest

None.

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Authors and Affiliations

  1. Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bldg 10, CRC, 10 Center Drive, Bethesda, MD, USA

    P. Lee, R. J. Brychta, J. Linderman, S. Smith, K. Y. Chen & F. S. Celi

  2. Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 10 Center Drive, Bethesda, MD, USA

    M. T. Collins

  3. PET Department, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD, USA

    P. Herscovitch & C. Millo

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  1. P. Lee
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  2. R. J. Brychta
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  3. M. T. Collins
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  4. J. Linderman
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  5. S. Smith
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  6. P. Herscovitch
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  7. C. Millo
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  8. K. Y. Chen
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  9. F. S. Celi
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Corresponding author

Correspondence to P. Lee.

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Table S1

Multiple regression analysis in females with age, lean body mass, and fat mass as independent variables and total bone mineral density as dependent variable (DOC 67 kb)

Table S2

Multiple regression analysis in females with age, lean body mass, and fat mass as independent variables and spine bone mineral density as dependent variable (DOC 67 kb)

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Lee, P., Brychta, R.J., Collins, M.T. et al. Cold-activated brown adipose tissue is an independent predictor of higher bone mineral density in women. Osteoporos Int 24, 1513–1518 (2013). https://doi.org/10.1007/s00198-012-2110-y

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  • DOI: https://doi.org/10.1007/s00198-012-2110-y

Keywords

  • Bone mineral density
  • Brown adipose tissue
  • Human
  • Metabolism
  • Thermogenesis