Effect of whole-body vibration on BMD: a systematic review and meta-analysis
- 1.3k Downloads
Our systematic review and meta-analysis of randomized controlled trials (RCTs) examining whole-body vibration (WBV) effect on bone mineral density (BMD) found significant but small improvements in hip areal BMD (aBMD) in postmenopausal women and in tibia and spine volumetric BMD in children/adolescents, but not in other BMD measurements in postmenopausal women and young adults.
Animal experiments report anabolic bone changes in response to WBV, but data in humans are limited. Our objective is to conduct a systematic review and meta-analysis of RCTs examining WBV effect on BMD.
Eligible RCTs included randomized or quasi-randomized trials, with follow-up of ≥6 months, examining WBV effects on BMD in ambulatory individuals without secondary causes of osteoporosis. The weighted mean differences between WBV and control groups in absolute pre-post change in spine and hip aBMD, and in spine and tibia trabecular volumetric BMD (vBMD) were calculated.
Eight RCTs in postmenopausal women (five RCTs), young adults (one RCT), and children and adolescents (two RCTs) were included. The regimens were heterogeneous, study durations were relatively short, and available data was mostly per-protocol. In postmenopausal women, WBV was found to significantly increase hip aBMD (0.015 g cm−2; 95% confidence interval (CI), 0.008–0.022; n = 131) versus controls, but not spine aBMD (n = 181) or tibia trabecular vBMD (n = 29). In young adults, WBV did not increase spine or hip bone mineral content, or tibia trabecular vBMD (n = 53). In children and adolescents, WBV significantly increased spine (6.2 mg cm−3; 95% CI, 2.5–10.0; n = 65) and tibia (14.2 mg cm−3; 95% CI, 5.2–23.2; n = 17) trabecular vBMD.
We found significant but small improvements in BMD in postmenopausal women and children and adolescents, but not in young adults. WBV is a promising new modality, but before recommendations can be made for clinical practice, large-scale long-term studies are needed to determine optimal magnitude, frequency, and duration.
KeywordsBone mineral density Meta-analysis Quantitative computed tomography Whole-body vibration
- 13.Kolata G (2007) Low buzz may give mice better bones and less fat. N Y Times 10:F6Google Scholar
- 14.Wikimedia Foundation Inc (2009) Whole-body vibration. In: Wikipedia The Free Encyclopedia. Available via http://en.wikipedia.org/wiki/Whole_body_vibration. Accessed 10 Jul 2009
- 16.Rubin C, Pope M, Fritton JC, Magnusson M, Hansson T, McLeod K (2003) Transmissibility of 15-Hertz to 35-Hertz vibrations to the human hip and lumbar spine: determining the physiologic feasibility of delivering low-level anabolic mechanical stimuli to skeletal regions at greatest risk of fracture because of osteoporosis. Spine 28:2621–2627CrossRefPubMedGoogle Scholar
- 19.Higgins J, Green S (2008) Cochrane's handbook for systematic reviews of interventions version 5.0.1. In: The Cochrane Collaboration. Available via http://www.cochrane-handbook.org. Accessed 10 Jul 2009
- 21.Nelson DA, Norris SA, Gilsanz V (2006) Childhood and adolescence. In: Rosen CJ (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism, 7th edn. American Society for Bone and Mineral Research, Washington, pp 55–63Google Scholar
- 22.Reid IR (2006) Menopause. In: Rosen CJ (ed) Primer on the metabolic bone diseases and disorders of mineral metabolism, 7th edn. American Society for Bone and Mineral Research, Washington, pp 68–70Google Scholar
- 29.Torvinen S, Kannus P, Sievanen H, Jarvinen TA, Pasanen M, Kontulainen S, Nenonen A, Jarvinen TL, Paakkala T, Jarvinen M, Vuori I (2003) Effect of 8-month vertical whole body vibration on bone, muscle performance, and body balance: a randomized controlled study. J Bone Miner Res 18:876–884CrossRefPubMedGoogle Scholar
- 30.Verschueren SM, Roelants M, Delecluse C, Swinnen S, Vanderschueren D, Boonen S (2004) Effect of 6-month whole body vibration training on hip density, muscle strength, and postural control in postmenopausal women: a randomized controlled pilot study. J Bone Miner Res 19:352–359CrossRefPubMedGoogle Scholar
- 33.Bonnick SL (2004) Changes in bone density. In: Bone densitometry in clinical practice: application and interpretation, 2nd edn. Human Press Inc, Totowa, p 279Google Scholar
- 36.Wolff J (1986) The law of bone remodeling. Springer, BerlinGoogle Scholar