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Resistive vibration exercise attenuates bone and muscle atrophy in 56 days of bed rest: biochemical markers of bone metabolism

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Abstract

Summary

During and after prolonged bed rest, changes in bone metabolic markers occur within 3 days. Resistive vibration exercise during bed rest impedes bone loss and restricts increases in bone resorption markers whilst increasing bone formation.

Introduction

To investigate the effectiveness of a resistive vibration exercise (RVE) countermeasure during prolonged bed rest using serum markers of bone metabolism and whole-body dual X-ray absorptiometry (DXA) as endpoints.

Methods

Twenty healthy male subjects underwent 8 weeks of bed rest with 12 months follow-up. Ten subjects performed RVE. Blood drawings and DXA measures were conducted regularly during and after bed rest.

Results

Bone resorption increased in the CTRL group with a less severe increase in the RVE group (p = 0.0004). Bone formation markers increased in the RVE group but decreased marginally in the CTRL group (p < 0.0001). At the end of bed rest, the CTRL group showed significant loss in leg bone mass (−1.8(0.9)%, p = 0.042) whereas the RVE group did not (−0.7(0.8)%, p = 0.405) although the difference between the groups was not significant (p = 0.12).

Conclusions

The results suggest the countermeasure restricts increases in bone resorption, increased bone formation, and reduced bone loss during bed rest.

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Acknowledgements

The authors wish to thank the subjects who participated in the study and the staff of ward 18A at the Charité Campus Benjamin Franklin Hospital, Berlin, Germany. The Berlin Bed-Rest Study was supported by grant 14431/02/NL/SH2 from the European Space Agency. The investigations in the current study were supported by grant 50WB0522 from the Deutschen Zentrum für Luft- und Raumfahrt (German Aerospace Center). The Berlin Bed-Rest Study was also sponsored by the Charité Campus Benjamin Franklin, MSD Sharp & Dohme, Lilly Germany, Novartis, Servier Germany, P&G, Wyeth, Siemens, and Seca. Daniel L. Belavý was supported by a post-doctoral fellowship from the Alexander von Humboldt Foundation.

Conflicts of interest

Dieter Felsenberg and Jörn Rittweger are acting as consultants to the European Space Agency and Novotec Medical for the exploitation of this study’s results.

All other authors have no conflicts of interest.

Author information

Authors and Affiliations

  1. Zentrum für Muskel- und Knochenforschung, Charité Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany

    G. Armbrecht, D. L. Belavý, U. Gast, M. Bongrazio, F. Touby, G. Beller & D. Felsenberg

  2. Labor Limbach, Abteilung für Endokrinologie und Onkologie, Im Breitspiel 15, 69126, Heidelberg, Germany

    H. J. Roth

  3. Zentralinstitut für Laboratoriumsmedizin und Pathobiochemie, Charité Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany

    F. H. Perschel

  4. Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, Oxford Road, Manchester, M1 5GD, UK

    J. Rittweger

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  1. G. Armbrecht
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Correspondence to G. Armbrecht.

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Armbrecht, G., Belavý, D.L., Gast, U. et al. Resistive vibration exercise attenuates bone and muscle atrophy in 56 days of bed rest: biochemical markers of bone metabolism. Osteoporos Int 21, 597–607 (2010). https://doi.org/10.1007/s00198-009-0985-z

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  • DOI: https://doi.org/10.1007/s00198-009-0985-z

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