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Bone microdamage

  • Bone Quality Seminars: Ultrastructure
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References

  1. Frost HM (1960) Presence of microscopic cracks in vivo in bone. Henry Ford Medical Bulletin 8:27–35

    Google Scholar 

  2. Burr DB, Martin DB, Schaffler MB, Radin EL (1985) Bone remodeling in response to in vivo fatigue microdamage. J Biomech 18:189–200

    Article  PubMed  CAS  Google Scholar 

  3. Mori S, Burr DB (1993) Increased intracortical remodeling following fatigue damage. Bone 14:103–109

    Article  PubMed  CAS  Google Scholar 

  4. Bentolila V, Boyce TM, Fyhrie DP et al (1998) Intracortical remodeling in adult rat long bones after fatigue loading. Bone 23:275–281

    Article  PubMed  CAS  Google Scholar 

  5. Burr DB (2002) Targeted and non targeted remodeling. Bone 30:2–4

    Article  PubMed  CAS  Google Scholar 

  6. Parfitt AM (2002) Targeted and non targeted bone remodeling: relationship to basic multicellular unit origination and progression. Bone 30:5–7

    Article  PubMed  CAS  Google Scholar 

  7. Forwood MR, Parker AW (1989) Microdamage in response to repetitive torsional loading in the rat tibia. Calcif Tissue Int 45:47–53

    Article  PubMed  CAS  Google Scholar 

  8. O'Brien FJ, Taylor D, Dickson GR, Lee TC (2000) Visualization of three dimensional microcracks in compact bone. J Anat 197:413–420

    Article  PubMed  Google Scholar 

  9. Taylor D, Lee TC (1998) Measuring the shape and size of microcracks in bone. J Biomech 31:1177–1180

    Article  PubMed  CAS  Google Scholar 

  10. Mori S, Harruff R, Ambrosius W, Burr DB (1997) Trabecular bone volume and microdamage accumulation in the femoral heads of women with and without femoral neck fractures. Bone 21:521–526

    Article  PubMed  CAS  Google Scholar 

  11. Fazzalari NL, Kuliwaba JS, Forwood MR (2002) Cancellous bone microdamage in the proximal femur: influence of age and osteoarthritis on damage morphology and regional distribution. Bone 31:697–702

    Article  PubMed  CAS  Google Scholar 

  12. Schaffler MB, Choi K, Milgrom C (1995) Aging and matrix microdamage accumulation in human compact bone. Bone 17:521–525

    Article  PubMed  CAS  Google Scholar 

  13. Wenzel TE, Schaffler MB, Fyhrie DP (1996) In vivo trabecular microcracks in human vertebral bone. Bone 19:89–95

    Article  PubMed  CAS  Google Scholar 

  14. Schaffler MB, Radin EL, Burr DB (1989) Mechanical and morphological effects of strain rate on fatigue of compact bone. Bone 10:207–214

    Article  PubMed  CAS  Google Scholar 

  15. Pattin CA, Caler WE, Carter DR (1996) Cyclic mechanical property degradation during fatigue loading of cortical bone. J Biomech 29:69–79

    Article  PubMed  CAS  Google Scholar 

  16. Schaffler MB, Radin EL, Burr DB (1990) Long-term fatigue behavior of compact bone at low strain magnitude and rate. Bone 11:321–326

    Article  PubMed  CAS  Google Scholar 

  17. Zioupos P, Currey JD (1994) The extent of microcracking and the morphology of microcracks in damaged bone. J Mat Sci 29:978–986

    Article  Google Scholar 

  18. Forwood MR, Burr DB, Takano Y, Eastman DF, Smith PN, Schwardt JD (1995) Risedronate treatment does not increase microdamage in the canine femoral neck. Bone 16:643–650

    Article  PubMed  CAS  Google Scholar 

  19. Mashiba T, Hirano T, Turner CH, Forwood M, Johnston CC, Burr DB (2000) Suppressed bone turnover by bisphosphonates increases mirodamage accumulation and reduces some biomechanical properties in dog rib. J Bone Miner Res 15:613–620

    Article  PubMed  CAS  Google Scholar 

  20. Mashiba T, Turner CH, Hirano T, Forwood M, Johnston CC, Burr DB (2001) Effects of suppressed bone turnover by bisphosphonates on microdamage accumulation and biochemical properties in clinically relevant skeletal sites in beagles. Bone 28:524–531

    Article  PubMed  CAS  Google Scholar 

  21. Allen MR, Iwata K, Phipps R, Burr DB (2006) Alterations in canine vertebral bone turnover, microdamage accumulation, and biomechanical properties following 1-year treatment with clinical treatment doses of risedronate or alendronate. Bone 39:872–879

    Article  PubMed  CAS  Google Scholar 

  22. Stepan JJ, Burr DB, Pavo I, Sipos A, Michalska D, Li J, Fahrleitner-Pammer A, Petto H, Westmore M, Michalsky D, Sato M, Dobnig H (2007) Low bone mineral density is associated with bone microdamage accumulation in postmenopausal women. Bone 41:378–385

    Article  PubMed  Google Scholar 

  23. Chapurlat RD, Arlot M, Burt-Pichat B, Chavassieux P, Roux JP, Portero-Muzy N, Delmas PD (2007) Microcrack frequency and bone remodelling in postmenopausal osteoporotic women: a bone biopsy study. J Bone Miner Res; 22:1502–1509

    Article  PubMed  CAS  Google Scholar 

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Chapurlat, R.D. Bone microdamage. Osteoporos Int 20, 1033–1035 (2009). https://doi.org/10.1007/s00198-009-0859-4

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  • DOI: https://doi.org/10.1007/s00198-009-0859-4

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