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Investigation of bone with synchrotron radiation imaging: from micro to nano

  • Bone Quality Seminars: Ultrastructure
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References

  1. Salomé M, Peyrin F, Cloetens P, Odet C, Laval-Jeantet AM, Baruchel J, Spanne PA (1999) Synchrotron radiation microtomography system for the analysis of trabecular bone samples. Med Phys 26(10):2194–2204

    Article  PubMed  Google Scholar 

  2. Nuzzo S, Peyrin F, Cloetens P, Baruchel J, Boivin G (2002) Quantification of the degree of mineralization of bone in three dimensions using synchrotron radiation microtomography. Med Phys 29(11):2672–2681

    Article  PubMed  Google Scholar 

  3. Nuzzo S, Lafage-Proust MH, Martin-Badosa E, Boivin G, Thomas T, Alexandre C, Peyrin F (2002) Synchrotron radiation microtomography allows the analysis of three-dimensional microarchitecture and degree of mineralization of human iliac crest biopsy specimens: effects of etidronate treatment. J Bone Min Res 17(8):1372–1382

    Article  CAS  Google Scholar 

  4. Chappard C, Peyrin F, Bonnassie A, Lemineur G, Brunet-Imbault B, Lespessailles E, Benhamou CL (2006) Subchondral bone micro-architectural alterations in osteoarthritis: a synchrotron micro-computed tomography study. Osteoarthritis Cartilage 14(3):215–223

    Article  PubMed  CAS  Google Scholar 

  5. Bousson V, Peyrin F, Bergot C, Hausard M, Sautet A, Laredo JD (2004) Cortical bone in the human femoral neck: three-dimensional appearance and porosity using synchrotron radiation. J Bone Miner Res 19(5):794–801

    Article  PubMed  Google Scholar 

  6. Martin-Badosa E et al (2003) Excised bone structures in mice: imaging at three-dimensional synchrotron radiation micro CT. Radiology 229(3):921–928

    Article  PubMed  Google Scholar 

  7. Yao W, Balooch G, Balooch M, Jiang Y, Nalla RK, Kinney J, Wronski TJ, Lane NE (2006) Sequential treatment of ovariectomized mice with bFGF and risedronate restored trabecular bone microarchitecture and mineralization. Bone 39(3):460–469

    Article  PubMed  CAS  Google Scholar 

  8. Burghardt AJ, Wang Y, Elalieh H, Thibault X, Bikle D, Peyrin F, Majumdar S (2007) Evaluation of fetal bone structure and mineralization in IGF-I deficient mice using synchrotron radiation microtomography and Fourier transform infrared spectroscopy. Bone 40(1):160–168

    Article  PubMed  CAS  Google Scholar 

  9. Hengsberger S, Enstroem J, Peyrin F, Zysset P (2003) How is the indentation modulus of bone tissue related to its macroscopic elastic response? A validation study. J Biomech 36(10):1503–1509

    Article  PubMed  CAS  Google Scholar 

  10. Schneider P, Stauber M, Voide R, Stampanoni M, Donahue LR, Müller R (2007) Ultra-structural properties in cortical bone vary greatly in two inbred strains of mice as assessed by synchrotron light based micro- and nano-CT. J Bone Miner Res 22(10):1557–1570

    Article  PubMed  Google Scholar 

  11. Mokso R, Cloetens P, Maire E, Ludwig W, Buffière J-Y (2007) Nanoscale zoom tomography with hard X rays using Kirkpatrick–Baez optics. Appl Phys Lett 90:144104

    Article  Google Scholar 

  12. Langer M, Cloetens P, Guigay JP, Peyrin F (2008) Quantitative comparison of direct phase retrieval algorithms in in-line phase tomography. Med Phys 35:4556–66

    Article  PubMed  Google Scholar 

  13. Eichert D, Gregoratti L, Kaulich B, Marcello A, Melpignano P, Quaroni L, Kiskinova M (2007) Imaging with spectroscopic micro-analysis using synchrotron radiation. Anal Bioanal Chem 389(4):1121–1132

    Article  PubMed  CAS  Google Scholar 

  14. Behets GJ, Verberckmoes SC, Oste L, Bervoets AR, Salomé M, Cox AG, Denton J, De Broe ME, D’Haese PC (2005) Localization of lanthanum in bone of chronic renal failure rats after oral dosing with lanthanum carbonate. Kidney Int 67(5):1830–1836

    Article  PubMed  CAS  Google Scholar 

  15. Fuchs RK, Allen MR, Condon KW, Reinwald S, Miller LM, McClenathan D, Keck B, Phipps RJ, Burr DB (2008) Strontium ranelate does not stimulate bone formation in ovariectomized rats. Osteoporos Int. 19:1331–41

    Article  PubMed  CAS  Google Scholar 

  16. Paschalis EP, Glass EV, Donley DW, Eriksen EF (2005) Bone mineral and collagen quality in iliac crest biopsies of patients given teriparatide: new results from the fracture prevention trial. J Clin Endocrinol Metab 90(8):4644–4649

    Article  PubMed  CAS  Google Scholar 

  17. Miller LM, Vairavamurthy V, Chance MR, Mendelsohn R, Paschalis EP, Betts F, Boskey AL (2001) In situ analysis of mineral content and crystallinity in bone using infrared micro-spectroscopy of the nu(4) PO(4)(3-) vibration. Biochim Biophys Acta 1527(1–2):11–19

    PubMed  CAS  Google Scholar 

  18. Huang RY, Miller LM, Carlson CS, Chance MR (2003) In situ chemistry of osteoporosis revealed by synchrotron infrared microspectroscopy. Bone 33(4):514–521

    Article  PubMed  CAS  Google Scholar 

  19. Miller LM, Little W, Schirmer A, Sheik F, Busa B, Judex S (2007) Accretion of bone quantity and quality in the developing mouse skeleton. J Bone Miner Res 22(7):1037–1045

    Article  PubMed  Google Scholar 

  20. Nuzzo S, Meneghini C, Braillon P, Bouvier R, Mobilio S, Peyrin F (2003) Microarchitectural and physical changes during fetal growth in human vertebral bone. J Bone Miner Res 18(4):760–768

    Article  PubMed  CAS  Google Scholar 

  21. Mastrogiacomo M, Papadimitropoulos A, Cedola A, Peyrin F, Giannoni P, Pearce SG, Alini M, Giannini C, Guagliardi A, Cancedda R (2007) Engineering of bone using bone marrow stromal cells and a silicon-stabilized tricalcium phosphate bioceramic: evidence for a coupling between bone formation and scaffold resorption. Biomaterials 28(7):1376–1384

    Article  PubMed  CAS  Google Scholar 

  22. Fratzl P, Gupta HS, Paschalis EP, Roschger P (2004) Structure and mechanical quality of the collagen-mineral nano-composite in bone. J Mater Chem 14:2115–2123

    Article  CAS  Google Scholar 

  23. Hiller JC, Wess TJ (2006) The use of small-angle X-ray scattering to study archaeological and experimentally altered bone. J Archaeol Sci 33(4):560–572

    Article  Google Scholar 

  24. Moger CJ, Barrett R, Bleuet P, Bradley DA, Ellis RE, Green EM, Knapp KM, Muthuvelu P, Winlove CP (2007) Regional variations of collagen orientation in normal and diseased articular cartilage and subchondral bone determined using small angle X-ray scattering (SAXS). Osteoarthr Cartil 15(6):682–687

    Article  PubMed  CAS  Google Scholar 

  25. Seidel R, Gourrier A, Burghammer M, Riekel C, Jeronimidis G, Paris O (2008) Mapping fibre orientation in complex-shaped biological systems with micrometre resolution by scanning X-ray microdiffraction. Micron 39(2):198–205

    Article  PubMed  Google Scholar 

  26. Peyrin F, Salome M, Cloetens P, Laval-Jeantet AM, Ritman E, Rüegsegger P (1998) Micro-CT examinations of trabecular bone samples at different resolutions: 14, 7 and 2 micron level. Technol Health Care 6(5–6):391–401

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. INSERM U630, CREATIS-LRMN; CNRS UMR 5220; INSA-Lyon, F-69621, Lyon, Villeurbanne, France

    F. Peyrin

  2. Université de Lyon, F-69622, Lyon, Villeurbanne, France

    F. Peyrin

  3. ESRF, BP 220, 38043, Grenoble Cedex, France

    F. Peyrin

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Peyrin, F. Investigation of bone with synchrotron radiation imaging: from micro to nano. Osteoporos Int 20, 1057–1063 (2009). https://doi.org/10.1007/s00198-009-0855-8

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  • DOI: https://doi.org/10.1007/s00198-009-0855-8

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