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Effects of lean and fat mass on bone mineral density and arterial stiffness in elderly men

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Abstract

Summary

The role of body composition on arterial stiffness and osteoporosis remains unclear, especially in the elderly male population. Our results indicate that elderly men with high lean mass and low fat mass exhibit the best arterial and bone profile with the lowest arterial stiffness and the highest bone mineral density.

Introduction

The aim of this study was to evaluate the influence of fat and lean mass on both arterial stiffness and bone mass density (BMD) in elderly men.

Methods

This study was performed in 169 French males over 60 years old. Aortic stiffness was assessed by carotid/femoral pulse wave velocity (PWV). BMD and body composition were determined with a dual-energy X-ray absorptiometry device in the lumbar spine L1–L4, femoral neck, and total body.

Results

Lean mass was positively correlated with the three T scores accounting for 11.6%, 26.6%, and 12.2% of the variability in the lumbar spine L1–L4, femoral neck, and total body BMD T scores, respectively. Fat mass had no effect on BMD. However, fat mass was positively correlated with aortic PWV, accounting for 9.8% of its variability. Lean mass was not a determinant of PWV. Hypertension, diabetes, and dyslipidemia were associated with higher PWV but had no effect on BMD.

Conclusions

In males from a general population over 60 years of age, bone and arterial aging are differently influenced by lean and fat mass. Our results indicate that elderly men with high lean mass and low fat mass exhibit the best arterial and bone profile with the lowest arterial stiffness and the highest BMD.

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Acknowledgments

The study has been realized in collaboration with the Clinical Investigation Center CIC-INSERM, CHU of Nancy and was granted from the University Hospital of Nancy (CPRC-2005–2006), as well as from the “Plan Pluriformation” (PPF-2006) of the French Ministry of Research. No other funding, from public or private agencies, was used or received for this study. We thank Mr. Pierre Pothier for critical review of the manuscript.

Conflicts of interest

None.

Author information

Authors and Affiliations

  1. Department of Medicine and Geriatrics, Brabois Hospital, University Hospital of Nancy, Nancy, France

    A. Benetos, A. Zervoudaki, A. Kearney-Schwartz & C. Perret-Guillaume

  2. INSERM U684, University of Nancy, Nancy, France

    A. Benetos, A. Zervoudaki, P. Lacolley & C. Labat

  3. Clinical Investigation Center, University Hospital of Nancy, Nancy, France

    A. Kearney-Schwartz

  4. Department of Endocrinology, University Hospital of Nancy, Nancy, France

    V. Pascal-Vigneron & G. Weryha

Authors
  1. A. Benetos
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  2. A. Zervoudaki
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  3. A. Kearney-Schwartz
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  4. C. Perret-Guillaume
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  5. V. Pascal-Vigneron
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  6. P. Lacolley
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  7. C. Labat
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  8. G. Weryha
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Corresponding author

Correspondence to A. Benetos.

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Benetos, A., Zervoudaki, A., Kearney-Schwartz, A. et al. Effects of lean and fat mass on bone mineral density and arterial stiffness in elderly men. Osteoporos Int 20, 1385–1391 (2009). https://doi.org/10.1007/s00198-008-0807-8

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  • DOI: https://doi.org/10.1007/s00198-008-0807-8

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