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RETRACTED ARTICLE: Nitrate use and changes in bone mineral density: the Canadian Multicentre Osteoporosis Study

Osteoporosis International volume 20, pages 737–744 (2009)Cite this article

This article was retracted on 01 December 2016

Abstract

Summary

Nitrates may have beneficial effects on bone. To determine if nitrates were associated with increased bone mineral density (BMD), we conducted a secondary analysis using data from subjects in a prospective study. Subjects reporting nitrate use had increased BMD compared with non-users, confirming that nitrates have positive BMD effects in women and men.

Introduction

Prior studies suggest positive associations between nitrates and bone.

Methods

We used linear regression models, stratified by gender and adjusted for age, weight, and baseline differences, to determine the association between daily nitrate use and BMD among subjects participating in the Canadian Multicentre Osteoporosis Study. All results are reported as annualised percent change in BMD at the hip and spine among nitrate users compared to non-users.

Results

We included 1,419 men (71 reported daily nitrate use) and 2,587 women (97 reported daily nitrate use). Male non-users had decreased hip BMD (−1.3%; 95% confidence interval [95%CI] = −1.6 to −1.1) and increased spine BMD (2.8%; 95%CI = 2.5 to 3.1). Male nitrate users had increased hip BMD (1.4%; 95%CI = 0.1 to 2.8) and spine BMD (4.5%; 95%CI = 3.2 to 5.7). Among women, non-users had decreased hip BMD (−1.9; 95%CI = −2.1 to −1.7) and increased spine BMD (2.1%; 95%CI = 1.9 to 2.4) whilst users had an increase in hip BMD (2.0%; 95%CI = 1.2 to 2.8) and spine BMD (4.1%; 95%CI = 3.4 to 4.9).

Conclusion

Nitrate use is associated with increased BMD at the hip and spine in men and women.

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Acknowledgements

This study was supported by the Canadian Institutes of Health Research, Merck Frosst Canada, Eli Lilly Canada, Novartis Pharmaceuticals, The Alliance for Better Bone Health (Sanofi-Aventis and Procter and Gamble Pharmaceuticals Canada), The Dairy Farmers of Canada and The Arthritis Society.

Conflicts of interest

None.

Author information

Affiliations

  1. Medicine, University of Toronto, Toronto, ON, Canada

    S. A. Jamal & R. G. Josse

  2. Medicine, McGill University, Montreal, PQ, Canada

    D. Goltzman

  3. Medicine, University of Calgary, Calgary, AB, Canada

    D. A. Hanley

  4. Medicine, McMaster University, Hamilton, ON, Canada

    A. Papaioannou

  5. Medicine, University of British Columbia, Vancouver, BC, Canada

    J. C. Prior

  6. 76 Grenville Street, Suite 805, Toronto, ON, M5S 1B2, Canada

    S. A. Jamal

Authors
  1. S. A. Jamal
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  2. D. Goltzman
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  3. D. A. Hanley
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  4. A. Papaioannou
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  5. J. C. Prior
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  6. R. G. Josse
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Corresponding author

Correspondence to S. A. Jamal.

Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s00198-016-3843-9.

The majority of the authors of this work believe the original conclusions presented have been compromised by inconsistencies in the data and the article should be retracted; a decision supported by the Editors of Osteoporosis International. The following authors agree with this retraction decision: David Goltzman; David A. Hanley; Alexandra Papaioannou; Jerilynn C. Prior; Robert G. Josse. The following author could not be reached for comment: Sophie A. Jamal The authors deeply regret the impact of this action on the work of other investigators.

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Jamal, S.A., Goltzman, D., Hanley, D.A. et al. RETRACTED ARTICLE: Nitrate use and changes in bone mineral density: the Canadian Multicentre Osteoporosis Study. Osteoporos Int 20, 737–744 (2009). https://doi.org/10.1007/s00198-008-0727-7

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  • DOI: https://doi.org/10.1007/s00198-008-0727-7

Keywords

  • Bone mineral density
  • Men
  • Organic nitrates
  • Prospective study
  • Women