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Association between caffeine intake and bone mass among young women: potential effect modification by depot medroxyprogesterone acetate use

Abstract

Summary

This study assessed associations between habitual caffeine intake and bone mass among young women. Analyses of the entire study population revealed no significant associations, while analyses restricted to women using depot medroxyprogesterone acetate (DMPA) showed modest inverse associations between caffeine intake and bone mineral content (BMC).

Introduction

Some previous investigations among postmenopausal women suggest an inverse relationship between caffeine intake and bone mass, yet studies of this association among young women are few.

Methods

The association between habitual caffeine intake and bone mass was evaluated prospectively in a population-based cohort of 625 females, aged 14 to 40 years, adjusting for relevant biological and lifestyle factors. Caffeinated beverage intake was self-reported, and bone mineral content (BMC) and bone mineral density (BMD) were measured at baseline and every 6 months throughout a 24-month follow-up period using dual-energy x-ray absorptiometry.

Results

Cross-sectional analyses revealed no significant differences in mean BMC or BMD at baseline. Mean percentage and absolute changes in BMC and BMD were not associated with caffeine use. Repeated measures analyses similarly showed no significant association between caffeine intake at baseline and mean BMC or BMD measured during follow-up. However, among women using depot medroxyprogesterone acetate (DMPA), modest inverse associations between caffeine and BMC (but not BMD) were detected.

Conclusions

Our data suggest that heavy habitual consumption of caffeinated beverages does not adversely impact bone mass among young women in general. Greater caffeine intake may be associated with lower BMC among DMPA users.

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Acknowledgement

The authors acknowledge and appreciate the assistance of Ken Wu in preparing the data file.

Funding

This study was supported by grant number 2R01 HD031165 from the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD (Dr. Scholes).

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Correspondence to D. Scholes.

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Wetmore, C.M., Ichikawa, L., LaCroix, A.Z. et al. Association between caffeine intake and bone mass among young women: potential effect modification by depot medroxyprogesterone acetate use. Osteoporos Int 19, 519–527 (2008). https://doi.org/10.1007/s00198-007-0473-2

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Keywords

  • Bone content
  • Bone density
  • Caffeine
  • Depot medroxyprogesterone acetate
  • Longitudinal studies
  • Premenopause