Osteoporosis International

, Volume 17, Issue 12, pp 1820–1821 | Cite as

Low-carbohydrate, high-protein diets that restrict potassium-rich fruits and vegetables promote calciuria

  • C. S. Johnston
  • S. L. Tjonn
  • P. D. Swan
  • A. White
  • B. Sears
Letter to the Editor

In a recent issue of Osteoporosis International, Carter et al. reported that subjects adhering to a ketogenic, low-carbohydrate/high-protein (LCHP) diet for weight loss did not display increased bone turnover markers after 3 months compared to control subjects consuming a typical, unrestricted diet [1]. In this trial, weight loss averaged 6.4 kg versus 1.1 kg in the dieters and controls respectively (p=0.0008), whereas the mean urinary N-telopeptide increased by 1.6 versus 1.9 nmol BCE/mmol creatinine in the dieters and controls, respectively (p=0.86). Although this trial supports the view that high-protein diets do not adversely affect bone [2, 3], the dietary level of alkalizing minerals was not considered.

High-protein diets generate excessive amounts of acid due to the obligatory catabolism of sulfur amino acids, and bone may respond by releasing basic salts into the circulation [4]. Hence, if high-protein intakes are not accompanied by an adequate intake of alkalizing minerals,...


Bone Turnover Marker Urinary Calcium Sulfur Amino Acid Increase Bone Turnover Unrestricted Diet 
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Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2006

Authors and Affiliations

  • C. S. Johnston
    • 1
  • S. L. Tjonn
    • 2
  • P. D. Swan
    • 4
  • A. White
    • 1
  • B. Sears
    • 3
  1. 1.Department of NutritionArizona State UniversityMesaUSA
  2. 2.Conscious CuisineScottsdaleUSA
  3. 3.Inflammation Research FoundationMarbleheadUSA
  4. 4.Department of Exercise and WellnessArizona State UniversityMesaUSA

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