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Osteoporosis International

, Volume 17, Issue 12, pp 1820–1821 | Cite as

Low-carbohydrate, high-protein diets that restrict potassium-rich fruits and vegetables promote calciuria

  • C. S. Johnston
  • S. L. Tjonn
  • P. D. Swan
  • A. White
  • B. Sears
Letter to the Editor

In a recent issue of Osteoporosis International, Carter et al. reported that subjects adhering to a ketogenic, low-carbohydrate/high-protein (LCHP) diet for weight loss did not display increased bone turnover markers after 3 months compared to control subjects consuming a typical, unrestricted diet [1]. In this trial, weight loss averaged 6.4 kg versus 1.1 kg in the dieters and controls respectively (p=0.0008), whereas the mean urinary N-telopeptide increased by 1.6 versus 1.9 nmol BCE/mmol creatinine in the dieters and controls, respectively (p=0.86). Although this trial supports the view that high-protein diets do not adversely affect bone [2, 3], the dietary level of alkalizing minerals was not considered.

High-protein diets generate excessive amounts of acid due to the obligatory catabolism of sulfur amino acids, and bone may respond by releasing basic salts into the circulation [4]. Hence, if high-protein intakes are not accompanied by an adequate intake of alkalizing minerals,...

Keywords

Bone Turnover Marker Urinary Calcium Sulfur Amino Acid Increase Bone Turnover Unrestricted Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Carter JD, Vasey FB, Valeriano J (2006) The effect of a low-carbohydrate diet on bone turnover. Osteoporos Int May 23 [Epub ahead of print]Google Scholar
  2. 2.
    Roughead ZK, Johnson LK, Lykken GI, Hunt JR (2003) Controlled high-meat diets do not affect calcium retention or indices of bone status in healthy postmenopausal women. J Nutr 133:1020–1026PubMedGoogle Scholar
  3. 3.
    Kerstetter JE, O’Brien KO, Caseria DM, Wall DE, Insogna KL (2005) The impact of dietary protein on calcium absorption and kinetic measures of bone turnover in women. Clin Endocrinol Metab 90:26–31Google Scholar
  4. 4.
    Frassetto L, Morris RC, Sellmeyer DE, Todd K, Sebastian A (2001) Diet, evolution and aging. Eur J Nutr 40:200–213PubMedCrossRefGoogle Scholar
  5. 5.
    Sebastian A (2005) Dietary protein content and the diet’s net acid load: opposing effects on bone health. Am J Clin Nutr 82:921–923Google Scholar
  6. 6.
    Tucker KL, Hannan MT, Kiel DP (2001) The acid-base hypothesis: diet and bone in thee Framingham Osteoporosis Study. Eur J Nutr 40:231–237PubMedCrossRefGoogle Scholar
  7. 7.
    Johnston CS, Tjonn SL, Swan PD, White A, Hutchins H, Sears B (2006) Ketogenic low-carbohydrate diets have no metabolic advantage over nonketogenic low-carbohydrate diets. Am J Clin Nutr 83:1055–1061PubMedGoogle Scholar
  8. 8.
    Frassetto LA, Todd KM, Morris RC, Sebastian A (1998) Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents. Am J Clin Nutr 68:576–583PubMedGoogle Scholar
  9. 9.
    Lemann J (1999) Relationship between urinary calcium and net acid excretion as determined by dietary protein and potassium: a review. Nephron 81(suppl 1):18–25PubMedCrossRefGoogle Scholar
  10. 10.
    Alexy U, Remer T, Manz F, Neu CM, Schoenau E (2005) Long-term protein intake and dietary potential renal acid load are associated with bone remodeling and remodeling at the proximal radius in healthy children. Am J Clin Nutr 82:1107–1114PubMedGoogle Scholar
  11. 11.
    Lewis NM, Marcus MSK, Behling AR, Greger JL (1989) Calcium supplements and milk: effect on acid-base balance and on retention of calcium, magnesium, and phosphorus. Am J Clin Nutr 49:527–533PubMedGoogle Scholar

Copyright information

© International Osteoporosis Foundation and National Osteoporosis Foundation 2006

Authors and Affiliations

  • C. S. Johnston
    • 1
  • S. L. Tjonn
    • 2
  • P. D. Swan
    • 4
  • A. White
    • 1
  • B. Sears
    • 3
  1. 1.Department of NutritionArizona State UniversityMesaUSA
  2. 2.Conscious CuisineScottsdaleUSA
  3. 3.Inflammation Research FoundationMarbleheadUSA
  4. 4.Department of Exercise and WellnessArizona State UniversityMesaUSA

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